REAL-TIME FULL-DEPTH VISUALIZATION OF POSTERIOR OCULAR STRUCTURES: Comparison Between Full-Depth Imaging Spectral Domain Optical Coherence Tomography and Swept-Source Optical Coherence Tomography.
REAL-TIME FULL-DEPTH VISUALIZATION OF POSTERIOR OCULAR STRUCTURES: Comparison Between Full-Depth Imaging Spectral Domain Optical Coherence Tomography and Swept-Source Optical Coherence Tomography.
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DOI：
10.1097/iae.0000000000000842
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发表时间：
2016-06
期刊：
影响因子：
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通讯作者：
Freeman WR
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文献类型：
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作者：
Barteselli G;Bartsch DU;Weinreb RN;Camacho N;Nezgoda JT;Marvasti AH;Freeman WR
比较全深度成像（FDI）光谱域光学相干断层扫描（SD-OCT）和扫频源（SS）-OCT对玻璃体视网膜脉络膜结构的实时可视化。在40只正常眼、40只黄斑病变眼和40只青光眼眼中获得了使用FDI SD-OCT（Heidelberg Spectralis）和SS-OCT（Topcon DRI OCT-1）的中心凹扫描。通过首先手动增强玻璃体视网膜界面然后增强脉络膜，同时平均每次OCT B扫描100次，获得FDI SD-OCT图像。通过对每次B扫描平均96次获得SS-OCT图像。在掩蔽和随机混合原始OCT图像后，两位独立的医生对黄斑前囊、指状交错区线和脉络膜-巩膜边界的可视化以及脉络膜结构的清晰度进行分级。在118例（98.3%）和45例（37.5%，p<0.001）病例中，FDID-OCT成功实现了玻璃体视网膜-脉络膜结构的实时全深度图像。在109只眼（90.8%）中，FDI SD-OCT成像在显示黄斑前囊前缘方面上级SS-OCT成像，FDI SD-OCT的平均分级为1.63 ± 0.53，SS-OCT的平均分级为0.39 ± 0.52（p<0.001）。在108只眼（90.0%）的脉络膜-巩膜边界可视化方面，SS-OCT与FDI-OCT相似，SS-OCT的平均分级为1.81 ± 0.39，FDI-OCT的平均分级为1.78 ± 0.38（p=0.566）。在两种成像仪器中，指状交错区线的可视化是相同的（p=1.000）。使用SS-OCT的脉络膜结构的锐度大于使用FDI-OCT的脉络膜结构的锐度（p<0.001）。使用SD-OCT的手动双增强FDI技术在扫描过程中真实的实时显示玻璃体和视网膜脉络膜结构之间提供了良好的折衷。相比之下，SS-OCT成像良好精细脉络膜细节。应根据其在临床环境中的应用选择合适的OCT技术和软件。
To compare the real-time visualization of vitreoretino-choroidal structures using Full Depth Imaging (FDI) spectral domain optical coherence tomography (SD-OCT) and swept source (SS)-OCT. Foveal scans using both FDI SD-OCT (Heidelberg Spectralis) and SS-OCT (Topcon DRI OCT-1) were obtained in 40 normal eyes, 40 eyes with macular pathologies, and 40 eyes with glaucoma. FDI SD-OCT images were obtained by manually enhancing the vitreoretinal interface first and then the choroid, while averaging each OCT B-scan 100 times. SS-OCT images were obtained by averaging each B-scan 96 times. After masking and randomly mixing the original OCT images, two independent physicians graded visualization of the premacular bursa, interdigitation zone line, and chorio-scleral boundary, as well as sharpness of choroidal structures. A real-time full-depth image of vitreoretino-choroidal structures was successfully achieved with FDI SD-OCT in 118 cases (98.3%) and with SS-OCT in 45 cases (37.5%, p<0.001). FDI SD-OCT imaging was superior to SS-OCT imaging in visualizing the anterior border of the premacular bursa in 109 eyes (90.8%), with average grading of 1.63 ± 0.53 for the FDI SD-OCT and 0.39 ± 0.52 for the SS-OCT (p<0.001). SS-OCT was similar to FDI SD-OCT in visualizing the chorio-scleral boundary in 108 eyes (90.0%), with average grading of 1.81 ± 0.39 for the SS-OCT and 1.78 ± 0.38 for the FDI-OCT (p=0.566). The visualization of the interdigitation zone line was identical in the two imaging instruments (p=1.000). The sharpness of the choroidal structures was greater with SS-OCT than with FDI-OCT (p<0.001). Manual double-enhancing FDI technique using SD-OCT provided a good compromise between vitreous and retino-choroidal structures visualization in real time during scanning procedure. In contrast, SS-OCT imaged well fine choroidal details. Appropriate OCT technology and software should be selected according to its application in clinical settings.