Vitamin D Metabolic Pathway Genes and Pancreatic Cancer Risk
Vitamin D Metabolic Pathway Genes and Pancreatic Cancer Risk
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DOI：
10.1371/journal.pone.0117574
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发表时间：
2015-03-23
期刊：
影响因子：
3.7
通讯作者：
Stolzenberg-Solomon, Rachael Z.
中科院分区：
文献类型：
--
作者：
Arem, Hannah;Yu, Kai;Stolzenberg-Solomon, Rachael Z.
关于维生素 D 状态与胰腺癌风险之间关系的证据并不一致。这种不一致可能部分归因于维生素 D 调节基因的变异。我们选择了 11 个维生素 D 相关基因（GC、DHCR7、CYP2R1、VDR、CYP27B1、CYP24A1、CYP27A1、RXRA、CRP2、CASR 和 CUBN）共计 213 个单核苷酸多态性 (SNP)，并检查了与胰腺腺癌的关联。我们的研究包括来自胰腺癌 PanScans-I-III 全基因组关联研究的 3,583 例胰腺癌病例和 7,053 例对照。我们使用自适应联合测试和自适应排名截断乘积统计进行路径和基因分析，使用无条件逻辑回归进行 SNP 分析，并根据年龄、性别、研究和人群分层进行调整。我们使用队列病例 (n = 713) 和对照 (n = 878) 的子集，通过循环维生素 D 浓度 (50 nmol/L) 对最显着的 SNP 进行效果修正。维生素 D 代谢途径与胰腺癌风险无关 (p = 0.830)。在各个基因中，没有一个基因与胰腺癌风险的显着性水平相关。
Evidence on the association between vitamin D status and pancreatic cancer risk is inconsistent. This inconsistency may be partially attributable to variation in vitamin D regulating genes. We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma. Our study included 3,583 pancreatic cancer cases and 7,053 controls from the genome-wide association studies of pancreatic cancer PanScans-I-III. We used the Adaptive Joint Test and the Adaptive Rank Truncated Product statistic for pathway and gene analyses, and unconditional logistic regression for SNP analyses, adjusting for age, sex, study and population stratification. We examined effect modification by circulating vitamin D concentration (50 nmol/L) for the most significant SNPs using a subset of cohort cases (n = 713) and controls (n = 878). The vitamin D metabolic pathway was not associated with pancreatic cancer risk (p = 0.830). Of the individual genes, none were associated with pancreatic cancer risk at a significance level of p