Matrix metalloproteinase expression and outcome in patients with breast cancer: analysis of a published database
Matrix metalloproteinase expression and outcome in patients with breast cancer: analysis of a published database
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DOI：
10.1093/annonc/mdn180
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发表时间：
2008-09-01
影响因子：
50.5
通讯作者：
Duffy, M. J.
中科院分区：
文献类型：
--
作者：
McGowan, P. M.;Duffy, M. J.
传统上，基质金属蛋白酶（MMPs）与癌症的侵袭和转移有关。由于它们在这些过程中的作用，已经研究了几种MMPs的潜在预后价值以及抗转移治疗的靶点。在这项研究中，我们使用了一个实验室可用的数据库，将17种不同MMP的信使RNA表达水平与乳腺癌患者的肿瘤特征和预后联系起来。在所研究的MMP中，只有MMP-1在肿瘤> 2cm时显著增加，
Traditionally, matrix metalloproteinases (MMPs) have been implicated in cancer invasion and metastasis. Because of their role in these processes, several MMPs have been investigated for potential prognostic value as well as targets for antimetastatic therapy. In this investigation, we used a publically available database to relate messenger RNA expression levels for 17 different MMPs to tumor characteristics and outcome in patients with breast cancer. Of the MMPs investigated, only MMP-1 was significantly increased in tumors >2 cm in size compared with those