Current trends and progress in clinical applications of oocyte cryopreservation.
Current trends and progress in clinical applications of oocyte cryopreservation.
复制标题
DOI：
10.1097/gco.0b013e32836091f4
复制
发表时间：
2013-06
影响因子：
2.1
通讯作者：
Seli E
中科院分区：
文献类型：
--
作者：
Cil AP;Seli E
探讨卵母细胞冷冻保存的临床应用趋势。尽管大约三十年前报道了第一例来自卵母细胞冷冻保存的活产，但卵母细胞冷冻保存的临床应用仅在过去十年中才取得重大进展。基于现有证据表明，供体卵母细胞玻璃化冷冻的成功率与新鲜供体卵母细胞IVF的成功率相似，美国生殖医学学会最近表示，卵母细胞冷冻保存不应再被视为医学适应症的实验性，而应与选择性卵母细胞冷冻保存无关。与此同时，一些关于卵母细胞冷冻保存态度的调查显示，选择性地用于延迟生育是目前卵母细胞冷冻保存最常见的适应症。最近，一项随机对照试验揭示了非供体卵母细胞冷冻保存安全性的重要证据，并证实玻璃化冷冻的临床成功率与新鲜卵母细胞IVF相当。有证据表明，与新鲜卵母细胞相比，供体和非供体冻存卵母细胞的IVF成功率相似，这将增加选择性卵母细胞冻存的利用率。对妇女进行卵母细胞冷冻保存的适当咨询需要建立基于年龄的冷冻保存卵母细胞用于各种适应症的临床成功率。
To delineate the current trends in the clinical application of oocyte cryopreservation. Although the first live birth from oocyte cryopreservation was reported approximately three decades ago, significant improvement in the clinical application of oocyte cryopreservation took place only over the past decade. On the basis of the available evidence suggesting that success rates with donor oocyte vitrification are similar to that of IVF with fresh donor oocytes, the American Society of Reproductive Medicine has recently stated that oocyte cryopreservation should no longer be considered experimental for medical indications, outlying elective oocyte cryopreservation. Meanwhile, a few surveys on the attitudes toward oocyte cryopreservation revealed that elective use for the postponement of fertility is currently the most common indication for oocyte cryopreservation. Most recently, a randomized controlled trial revealed important evidence on the safety of nondonor oocyte cryopreservation, and confirmed that the clinical success of vitrification is comparable to that of IVF with fresh oocytes. The evidence suggesting similar IVF success rates with both donor and nondonor cryopreserved oocytes compared with fresh oocytes will increase the utilization of elective oocyte cryopreservation. Appropriate counseling of women for oocyte cryopreservation requires the establishment of age-based clinical success rates with cryopreserved oocytes for various indications.