Hybrid liposomes affect cellular lipid constituents and caveolae structures
Hybrid liposomes affect cellular lipid constituents and caveolae structures
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混合脂质体影响细胞脂质成分和细胞膜穴结构
DOI：
10.1016/j.bmcl.2011.12.093
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发表时间：
2012
影响因子：
2.7
通讯作者：
Cao K
中科院分区：
文献类型：
--
作者：
吉川 豊;藤本重行;安井裕之;Cao K
我们研究了混合脂质体（HL）在癌细胞中诱导的脂质成分的变化。早在HL治疗后1小时，筏/小窝脂质鞘磷脂，神经酰胺和醚型PC的量发生了变化。此外，细胞膜胞质表面的小窝结构也发生了明显的变化。我们的研究结果表明，脂质组成的改变在小窝介导HL细胞凋亡的信号。
We examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer cells. As early as 1h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the cytoplasmic surface of the cell membrane were significantly changed. Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis.