Seeds of Locally Aligned Motion and Stress Coordinate a Collective Cell Migration.
Seeds of Locally Aligned Motion and Stress Coordinate a Collective Cell Migration.
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DOI：
10.1016/j.bpj.2015.11.001
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发表时间：
2015-12
影响因子：
3.4
通讯作者：
A. Zaritsky;Erik S. Welf;Yun-Yu Tseng;M. Angeles Rabadán;Xavier Serra-Picamal;X. Trepat;G. Danuser
中科院分区：
文献类型：
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作者：
A. Zaritsky;Erik S. Welf;Yun-Yu Tseng;M. Angeles Rabadán;Xavier Serra-Picamal;X. Trepat;G. Danuser
我们发现集体迁移是如何从细胞之间的机械信息传递中出现的。细胞速度和机械应力方向的局部对齐-一种被称为“趋侧性”的现象-在诱导协调迁移中起着至关重要的作用。单层边缘的前导细胞更好地调整速度和应力，以更快地向开放空间迁移。增强运动的局部种子然后对邻近细胞产生应力以引导它们的迁移。应力诱导的运动传播到单层以及沿着单层边界，以产生越来越大的协调迁移的细胞簇，其随着速度和应力的增强对齐而移动得更快。总之，我们的分析提供了一个细胞之间的长距离机械通信模型，其中plithotaxis将局部机械波动转化为整个组织的全局集体迁移。
We find how collective migration emerges from mechanical information transfer between cells. Local alignment of cell velocity and mechanical stress orientation—a phenomenon dubbed "plithotaxis"—plays a crucial role in inducing coordinated migration. Leader cells at the monolayer edge better align velocity and stress to migrate faster toward the open space. Local seeds of enhanced motion then generate stress on neighboring cells to guide their migration. Stress-induced motion propagates into the monolayer as well as along the monolayer boundary to generate increasingly larger clusters of coordinately migrating cells that move faster with enhanced alignment of velocity and stress. Together, our analysis provides a model of long-range mechanical communication between cells, in which plithotaxis translates local mechanical fluctuations into globally collective migration of entire tissues.