Alpha-galactosylceramide (αGalCer) enhances vaccine-induced protection in a model of ricin intoxication.
Alpha-galactosylceramide (αGalCer) enhances vaccine-induced protection in a model of ricin intoxication.
复制标题
α-半乳糖神经酰胺 (αGalCer) 增强蓖麻毒素中毒模型中疫苗诱导的保护。
DOI：
10.1080/21645515.2018.1461299
复制
发表时间：
2018
影响因子：
4.8
通讯作者：
Mantis,NicholasJ
中科院分区：
文献类型：
--
作者：
Yates,JenniferL;Leadbetter,Elizabeth;Mantis,NicholasJ
α -半乳糖神经酰胺（αGalCer）是一种来源于海绵的糖脂，是小鼠和人类不变自然杀伤T （iNKT）细胞的有效激活剂。因此，αGalCer是一种很有前途的疫苗佐剂，当与各种疫苗（包括生物防御候选疫苗）共同使用时，已被证明可以改善体液和细胞免疫。在目前的研究中，我们测试了αGalCer作为临床相关蓖麻毒素亚单位疫苗RiVax的佐剂的有效性。在小鼠模型中，α - galcer具有强效的佐剂作用，如抗蓖麻毒素IgG滴度的快速升高，血清毒素中和活性的加速发展，以及对致命蓖麻毒素攻击的增强保护。这些结果强调了α - galcer在对抗蓖麻毒素（一种速效生物威胁剂）疫苗时增强保护性免疫反应的潜力。
Alpha-galactosylceramide (αGalCer) is a glycolipid derived from a marine sponge that is a potent activator of both mouse and human invariant natural killer T (iNKT) cells. For that reason, αGalCer is a promising vaccine adjuvant that has been shown to improve both humoral and cellular immunity when co-administered with various vaccines, including candidate vaccines for biodefense. In the current study, we tested the effectiveness of αGalCer as an adjuvant for the clinically-relevant ricin toxin subunit vaccine, RiVax. αGalCer had a potent adjuvant effect, as shown by a rapid onset of anti-ricin IgG titers, accelerated development of serum toxin-neutralizing activity, and enhanced protection from lethal ricin challenge in a mouse model. These results underscore the potential of αGalCer to augment the protective immune response to a vaccine designed to counteract ricin toxin, a fast-acting biothreat agent.