Riluzole prevents oxaliplatin-induced cold allodynia via inhibition of overexpression of transient receptor potential melastatin 8 in rats
Riluzole prevents oxaliplatin-induced cold allodynia via inhibition of overexpression of transient receptor potential melastatin 8 in rats
复制标题
利鲁唑通过抑制大鼠体内瞬时受体电位 melastatin 8 的过度表达来预防奥沙利铂诱导的冷异常性疼痛
DOI：
10.1016/j.jphs.2018.10.006
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发表时间：
2018
期刊：
影响因子：
3.5
通讯作者：
Masuda S
中科院分区：
文献类型：
--
作者：
Yamamoto S;Egashira N;Tsuda M;Masuda S
奥沙利铂在大多数患者中引起急性感冒过敏。我们之前报道了来自奥沙利铂的草酸盐诱导大鼠背根神经节（DRG）瞬时受体电位美拉他汀8 （TRPM8）的冷异常性过表达。在这项研究中，我们检查了利鲁唑对奥沙利铂诱导的冷异常性痛的影响。在培养的DRG神经元中，利鲁唑抑制草酸盐诱导的薄荷醇（TRPM8激动剂）敏感细胞数量的增加。此外，利鲁唑可以预防奥沙利铂治疗大鼠的冷异常性痛和TRPM8 mRNA水平的升高。这些结果表明，利鲁唑可预防奥沙利铂诱导的DRG中TRPM8过表达的低温异常抑制。
Oxaliplatin causes acute cold hypersensitivity in most patients. We previously reported oxalate derived from oxaliplatin induced cold allodyniaviaoverexpression of transient receptor potential melastatin 8 (TRPM8) in the dorsal root ganglion (DRG) in rats. In this study, we examined the effect of riluzole on oxaliplatin-induced cold allodynia. In cultured DRG neurons, riluzole suppressed oxalate-induced increase of the number of menthol (TRPM8 agonist)-sensitive cells. Moreover, riluzole prevented cold allodynia and increase in levels of TRPM8 mRNA in oxaliplatin-treated rats. These results suggest that riluzole prevents oxaliplatin-induced cold allodyniaviainhibition of TRPM8 overexpression in the DRG.