Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells.
Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells.
复制标题
喷昔洛韦是一种选择性抑制剂，可抑制培养的人肝母细胞瘤细胞中乙型肝炎病毒的复制。
DOI：
10.1128/aac.40.5.1282
复制
发表时间：
1996
影响因子：
4.9
通讯作者：
Boyd,MR
中科院分区：
文献类型：
--
作者：
Korba,BE;Boyd,MR
Penciclovir [9-(4-hydroxy-3-hydroxymethylbut-1-yI)guanine], an effective antiherpesvirus agent, was found to be a potent and selective antiviral agent against intracellular hepatitis B virus (HBV) replication (drug concentration at which a 10-fold decrease in HBV DNA from the average level in an untreated culture was observed [EC90], 1.6 microM) and extracellular virion release (EC90, 0.7 microM) by cultured human hepatoblastoma (2.2.15) cells. Acyclovir and three other related 9-alkoxypurines with activity against either herpesviruses or human immunodeficiency virus were uniformly inactive against HBV. The activity of penciclovir is discussed in relation to recent findings related to its mode of action against HBV.
