Folic acid as second chemotactic substance in the cellular slime moulds.
Folic acid as second chemotactic substance in the cellular slime moulds.
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叶酸作为细胞粘菌中的第二种趋化物质。
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
John Tyler Bonner
中科院分区：
文献类型：
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作者：
Pauline Pan;E. M. Hall;John Tyler Bonner
一段时间以来，人们已经知道，在某些细胞粘霉菌物种中，在聚集阶段将阿米巴原虫吸引到中央收集点的物质是环状 AMP1-4。我们还能够证明，除了环AMP（以下称为细菌因子，或BF）之外，大肠杆菌还释放出另一种物质，它可以吸引盘基网柄菌5的营养变形虫。在这里，我们证明第二种引诱剂具有叶酸或其衍生物之一的特性。我们还表明，叶酸和相关化合物不仅能吸引盘基网柄菌（No. NC-4H）的营养变形虫，还能吸引其他六种阿米巴（Dictyostelium rosarium No. CC-7；D. mucoroides No. 11；D. purpureum No. 2；D. minutum No. V-3；Polysphondylium violaceum No. 1；D. mucoroides No. 11）。 P. pallidum No. 2)。对于后三个物种，环 AMP 不是聚集引诱剂（参考文献 6 和 J. T. B.、E. M. H.、S. Noller、F. B. Oleson 和 A. B. Roberts，正在准备中），这提出了一个有趣的问题：它们的阿克拉素是否可能与叶酸有关。
IT has been known for some time that in certain species of cellular slime moulds acrasin, the substance which attracts the amoebae to central collection points during the aggregation phase, is cyclic AMP1–4. We were also able to show that E. coli gave off another substance besides cyclic AMP (henceforth referred to as bacterial factor, or BF) which attracted the vegetative amoebae of Dictyostelium discoideum5. Here we demonstrate that this second attractant has the properties of folic acid or one of its derivatives. We also show that folic acid and related compounds not only attract the vegetative amoebae of D. discoideum (No. NC-4H) but also the amoebae of six other species (Dictyostelium rosarium No. CC-7; D. mucoroides No. 11; D. purpureum No. 2; D. minutum No. V-3; Polysphondylium violaceum No. 1; P. pallidum No. 2). For the latter three species cyclic AMP is not the aggregative attractant (ref. 6 and J. T. B., E. M. H., S. Noller, F. B. Oleson and A. B. Roberts, in preparation) which raises the interesting question of whether their acrasin might be related to the folates.