Necessity of IgE antibodies and mast cells for manifestation of resistance against larval Haemaphysalis longicornis ticks in mice.
Necessity of IgE antibodies and mast cells for manifestation of resistance against larval Haemaphysalis longicornis ticks in mice.
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IgE 抗体和肥大细胞对于表现出对小鼠长角血蜱幼虫的抵抗力是必要的。
DOI：
10.4049/jimmunol.144.1.259
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发表时间：
1990
影响因子：
4.4
通讯作者：
Yukihiko Kitamura
中科院分区：
文献类型：
--
作者：
H. Matsuda;N. Watanabe;Y. Kiso;S. Hirota;H. Ushio;Y. Kannan;M. Azuma;H. Koyama;Yukihiko Kitamura
遗传性肥大细胞缺陷的WBB 6 F1-W/Wv小鼠表现出明显的缺陷，表现出对长角血蜱幼虫的抵抗力，但其血清IgE水平在第二次蜱感染后增加了100倍以上。将从WBB 6 F1-W/Wv小鼠获得的免疫血清过继转移至已接受WBB 6 F1-+/+小鼠来源的培养肥大细胞皮内注射的其它WBB 6 F1-W/Wv小鼠。由于只有在肥大细胞和IgE抗体同时存在时才能检测到对蜱的抗性，因此速发型超敏反应似乎在对H.长角蜱
Genetically mast cell-deficient WBB6F1-W/Wv mice showed an apparent defect in manifestation of the resistance against larval Haemaphysalis longicornis ticks, but their serum IgE levels increased more than 100-fold after the second tick infestation. Immune sera obtained from the WBB6F1-W/Wv mice were adoptively transferred to the other WBB6F1-W/Wv mice which had received intracutaneous injections of WBB6F1-+/+ mouse-derived cultured mast cells. Because the resistance against ticks was detectable only when both mast cells and IgE antibodies were available, immediate hypersensitivity reaction appeared to have a physiologic role in the manifestation of the resistance against H. longicornis ticks.