Fish intake during pregnancy and early cognitive development of offspring
Fish intake during pregnancy and early cognitive development of offspring
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DOI：
10.1097/01.ede.0000129514.46451.ce
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发表时间：
2004-07-01
期刊：
影响因子：
5.4
通讯作者：
Golding, J
中科院分区：
文献类型：
--
作者：
Daniels, JL;Longnecker, MP;Golding, J
背景资料：鱼是许多对怀孕期间有益的营养素的来源，也是甲基汞等神经毒性污染物的来源。之前对鱼类摄入量与神经发育相关的研究主要集中在污染物可能造成的损害上，而食用鱼类的潜在益处相对未被探索。方法：我们评估了怀孕期间母体鱼类摄入量与后代语言和沟通能力早期发展之间的关联。一组7421名1991-1992年出生的英国儿童。母亲和孩子的鱼摄入量通过问卷调查来测量。儿童的认知发展进行了评估，在15个月大的麦克阿瑟沟通发展量表和丹佛发展筛选测试在18个月大的适应。汞在脐带组织的一个子集的1054 childrenResults：总汞浓度低，并没有与神经发育。母亲在怀孕期间和婴儿出生后的鱼类摄入量与较高的平均发育评分相关。例如，母亲每周吃鱼4次或更多次的儿童校正后的平均麦克阿瑟理解得分为72（95%置信区间= 71-74），而母亲不吃鱼的儿童校正后的平均麦克阿瑟理解得分为68（66-71）。
Background: Fish is a source of many nutrients that can be beneficial during pregnancy, as well as a source of neurotoxicant contaminants such as methylmercury. Previous investigations of fish intake in relation to neurodevelopment have focused on possible damage from contaminants, whereas potential benefits of fish consumption have been relatively unexploredMethods: We evaluated the association between maternal fish intake during pregnancy and offspring's early development of language and communication skills in a cohort of 7421 British children born in 1991-1992. Fish intake by the mother and child was measured by questionnaire. The child's cognitive development was assessed using adaptations of the MacArthur Communicative Development Inventory at 15 months of age and the Denver Developmental Screening Test at 18 months of age. Mercury was measured in umbilical cord tissue for a subset of 1054 childrenResults: Total mercury concentrations were low and were not associated with neurodevelopment. Fish intake by the mother during pregnancy, and by the infant postnatally, was associated with higher mean developmental scores. For example, the adjusted mean MacArthur comprehension score for children whose mothers con- sumed fish 4 or more times per week was 72 (95% confidence interval = 71-74), compared with 68 (66-71) among those whose mothers did not consume fish.Conclusions: When fish is not contaminated, moderate fish intake during pregnancy and infancy may benefit development.