Immune responses to HIV in the female reproductive tract, immunologic parallels with the gastrointestinal tract, and research implications.
Immune responses to HIV in the female reproductive tract, immunologic parallels with the gastrointestinal tract, and research implications.
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DOI：
10.1111/j.1600-0897.2010.00948.x
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Greenblatt RM
中科院分区：
文献类型：
--
作者：
Shacklett BL;Greenblatt RM
女性生殖道是粘膜相关淋巴组织的主要部位，也是 HIV 感染易感性的主要部位，但感染的组织部位以及 HIV 感染对这一重要粘膜组织的影响仍知之甚少。 CD4+ T 细胞和表达 HIV、CCR5 和 CXCR4 主要辅助受体的其他细胞类型在下生殖道（子宫颈内膜和阴道）和上生殖道（子宫颈内膜和子宫）中含量丰富，并且非常容易受到感染。女性生殖道中的抗病毒防御是由多种可溶性因子和粘膜效应细胞介导的，粘膜效应细胞的表型与血液中的对应细胞不同。女性生殖道的免疫学特征与肠道相似，主要发生与艾滋病毒相关的免疫损伤。女性生殖道对艾滋病毒感染和免疫发病机制的易感性为进一步研究提供了重要的新途径。
The female reproductive tract is a major site of mucosa-associated lymphoid tissue and susceptibility to HIV infection, yet the tissue site(s) of infection and the impact of HIV infection on this important mucosal tissue remain poorly understood. CD4+ T-cells and other cell types expressing the major coreceptors for HIV, CCR5 and CXCR4, are abundant in both the lower reproductive tract (endocervix and vagina) and the upper tract (endocervix and uterus), and are highly susceptible to infection. Antiviral defenses in the female reproductive tract are mediated by a variety of soluble factors, and by mucosal effector cells that differ phenotypically from their counterparts in blood. The immunologic characteristics of the female reproductive tract parallel those of the gut, where major HIV-related immunologic injury occurs. The susceptibility of the female reproductive tract to HIV infection and immunopathogenesis suggests important new avenues for further research.
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