Microwave-assisted protocols for the expedited synthesis of pyrazolo[1,5-a] and [3,4-d]pyrimidines
Microwave-assisted protocols for the expedited synthesis of pyrazolo[1,5-a] and [3,4-d]pyrimidines
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DOI：
10.1016/j.tetlet.2007.11.054
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发表时间：
2008-01-07
影响因子：
1.8
通讯作者：
Lindsley, Craig W.
中科院分区：
文献类型：
--
作者：
Daniels, R. Nathan;Kim, Kwangho;Lindsley, Craig W.
描述了用于快速合成官能化的吡唑并[1，5-a]嘧啶和吡唑并[3，4-b]嘧啶及其吡唑前体的一般、高产率的MAOS协议，遵循用于先导优化的迭代模拟文库合成策略。(C)2007爱思唯尔有限公司。保留所有权利。
General, high-yielding MAOS protocols for the expedited synthesis of functionalized pyrazolo[1,5-a]pyrimidines and pyrazolo[3,4-b]pyrimidines, as well as their pyrazole precursors, are described amenable to an iterative analogue library synthesis strategy for lead optimization. (c) 2007 Elsevier Ltd. All rights reserved.