Xanthone Natural Products via N-Heterocyclic Carbene Catalysis: Total Synthesis of Atroviridin
Xanthone Natural Products via N-Heterocyclic Carbene Catalysis: Total Synthesis of Atroviridin
复制标题
DOI：
10.1021/jo200303c
复制
发表时间：
2011-05-20
影响因子：
3.6
通讯作者：
Sato, Masayuki
中科院分区：
文献类型：
--
作者：
Suzuki, Yumiko;Fukuta, Yoshinori;Sato, Masayuki
阿特维里丁的全合成是通过n -杂环羰基催化氟苯衍生物的芳化，o-丙基化苯甲酮的Claisen环化，以及醌中间体的分子内1,4加成的线性途径完成的。该结果为山酮天然产物的制备提供了一条可行的途径。
The total synthesis of atroviridin has been accomplished by a linear route involving the N-heterocyclic carbene (NHC)-catalyzed aroylation of the fluorobenzene derivative, Claisen cyclization of the O-propargylated benzo-phenones, and intramolecular 1,4-addition of the quinone intermediates. The result provides a viable route to xanthone natural products.