Perirhinal cortex inactivation produces retrieval deficits in fear extinction to a discontinuous visual stimulus.
Perirhinal cortex inactivation produces retrieval deficits in fear extinction to a discontinuous visual stimulus.
复制标题
嗅周皮层失活会导致对不连续视觉刺激的恐惧消退的检索缺陷。
DOI：
10.1037/bne0000351
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发表时间：
2020
影响因子：
1.9
通讯作者：
Furtak, Sharon C.
中科院分区：
文献类型：
--
作者：
Potter, Nicole M.;Calub, Catrina A.;Furtak, Sharon C.
一些研究表明，嗅周皮层（PER）可能会跨时间或方式单位化刺激成分的功能。虽然PER已被证明是至关重要的恐惧收购不连续的刺激，PER的恐惧消退记忆的作用还没有得到评估。本研究评估了在连续或不连续条件刺激（CS）的恐惧消退训练过程中PER的参与。根据2个因素将大鼠随机分配到4组中的1组：CS类型（连续或不连续光）和预测试PER操作（蝇蕈醇灭活或盐水）。结果表明，PER失活损害了对两种CS类型的恐惧记忆，但PER失活只损害了对不连续光的消退记忆。这些结果表明PER在刺激单元化中的作用延伸到支持恐惧消退记忆的获得。
Several studies suggest that the perirhinal cortex (PER) may function to unitize stimulus components across time or modalities. While the PER has been shown to be critical for fear acquisition to discontinuous stimuli, the role of the PER in fear extinction memory has not been evaluated. The current study assessed the involvement of the PER during fear extinction training to a continuous or discontinuous conditioned stimulus (CS). Rats were randomly assigned to 1 of 4 groups based on 2 factors: the CS type (a continuous or discontinuous light) and a pretesting PER manipulation (muscimol inactivation or saline). Results showed that PER inactivation impaired fear memory to both CS types; however, PER inactivation had only impaired extinction memory to the discontinuous light. These results suggest the role of the PER in stimulus unitization extends to supporting the acquisition of fear extinction memory.