Controlled drug delivery systems in eradicating bacterial biofilm-associated infections
Controlled drug delivery systems in eradicating bacterial biofilm-associated infections
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DOI：
10.1016/j.jconrel.2020.10.038
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发表时间：
2021-02-20
影响因子：
10.8
通讯作者：
Shi, Linqi
中科院分区：
文献类型：
--
作者：
Liu, Yong;Li, Yuanfeng;Shi, Linqi
药物递送系统（DDS）在过去的几十年中取得了广泛的进展，以消除嵌入生物膜中的细菌，同时最大限度地减少抗菌剂对正常组织的副作用。它们具有解决固有的抗微生物剂抗性和抗微生物剂渗透到生物膜中的差的挑战的潜力。然而，开发用于对抗细菌生物膜的受控DDS的指南是有限的。本文综述了DDS的经典作用机理和数学模型，为可控DDS的发展奠定基础。根据生物被膜的形成过程，提出了构建可控DDS的策略，包括表面涂层、纤维、纳米颗粒作为DDS，以防止生物被膜的形成，根除细菌生物被膜相关感染。讨论了DDS设计中仍然存在的挑战，并提出了未来的发展方向。希望本文能为读者提供一个“路线图”，以促进新一代药物控释系统在抗菌领域的应用。
Drug delivery systems (DDS) have extensively progressed over the past decades for eradicating the bacteria embedded in biofilms while minimizing the side effects of antimicrobials on the normal tissues. They possess potential in solving the challenges of intrinsic antimicrobial-resistance and poor penetration of antimicrobials into biofilms. However, the guidelines for developing a controlled DDS for combating bacterial biofilms are limited. In this review, classical mechanisms and mathematical models of DDS were summarized in order to lay the foundation of controlled DDS development. Strategies for building controlled DDS were proposed based on the process of biofilm formation, including surface coatings, fibers, nanoparticles as DDS to prevent biofilm formation and eradicate bacterial biofilm-associated infections. The challenges that still remain in DDS design were discussed and future directions were suggested. We hope this review could give a "road map" to inspire readers and boost the development of the new generation of controlled drug release system for antimicrobial applications.