Metallothionein as an anti-inflammatory mediator.
Metallothionein as an anti-inflammatory mediator.
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DOI：
10.1155/2009/101659
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发表时间：
2009
影响因子：
4.6
通讯作者：
Satoh M
中科院分区：
文献类型：
--
作者：
Inoue K;Takano H;Shimada A;Satoh M
MT是一种高度保守、低分子量、富含半胱氨酸的金属蛋白，其功能的调节相关知识的整合对于阐明MT如何影响细胞过程是必要的。MT的表达在各种组织中由许多生理介质诱导/增强。MT的细胞积累取决于来自饮食的细胞锌的可用性。MT调节重金属如锌、镉或铜在生理条件下的结合和交换/转运，以及对其毒性的细胞保护，以及气体介质如羟基自由基或一氧化氮的释放。此外，据报道MT影响许多细胞过程，如基因表达、凋亡、增殖和分化。鉴于遗传方法，MT缺陷小鼠的表面健康状态反对MT的基本生物学作用;然而，这种分子在应激时在细胞/组织/器官中可能是关键的，因为MT表达也被各种应激诱发/增强。特别是，因为金属硫蛋白（MT）是由炎症应激诱导的，它在炎症中的作用是不言而喻的。此外，MT在各种器官/组织中的表达可以通过炎症刺激而增强，从而涉及炎症性疾病。本文就MT在各种炎症反应中的作用作一综述。
The integration of knowledge concerning the regulation of MT, a highly conserved, low molecular weight, cystein-rich metalloprotein, on its proposed functions is necessary to clarify how MT affects cellular processes. MT expression is induced/enhanced in various tissues by a number of physiological mediators. The cellular accumulation of MT depends on the availability of cellular zinc derived from the diet. MT modulates the binding and exchange/transport of heavy metals such as zinc, cadmium, or copper under physiological conditions and cytoprotection from their toxicities, and the release of gaseous mediators such as hydroxyl radicals or nitric oxide. In addition, MT reportedly affects a number of cellular processes, such as gene expression, apoptosis, proliferation, and differentiation. Given the genetic approach, the apparently healthy status of MT-deficient mice argues against an essential biological role for MT; however, this molecule may be critical in cells/tissues/organs in times of stress, since MT expression is also evoked/enhanced by various stresses. In particular, because metallothionein (MT) is induced by inflammatory stress, its roles in inflammation are implied. Also, MT expression in various organs/tissues can be enhanced by inflammatory stimuli, implicating in inflammatory diseases. In this paper, we review the role of MT of various inflammatory conditions.
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DOI：
10.1152/ajplung.00534.2005
发表时间：
2007-01-01
影响因子：
4.9
作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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