Increased Arterial Stiffness Amplifies the Association Between Home Blood Pressure Variability and Cardiac Overload The J-HOP Study
Increased Arterial Stiffness Amplifies the Association Between Home Blood Pressure Variability and Cardiac Overload The J-HOP Study
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DOI：
10.1161/hypertensionaha.119.14246
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发表时间：
2020-06-01
期刊：
影响因子：
8.3
通讯作者：
Kario, Kazuomi
中科院分区：
文献类型：
--
作者：
Ishiyama, Yusuke;Hoshide, Satoshi;Kario, Kazuomi
血压（BP）变异性增加，血流动力学应激的指标，导致心脏超负荷和更差的心血管预后。通过臂踝脉搏波传导速度（baPWV）评估的动脉僵硬度增加可能会放大每日家庭血压变异性与作为心脏超负荷指标的NT-proBNP（N末端B型利钠肽前体）之间的相关性。J-HOP（日本晨峰-家庭血压）研究参与者从至少有一个心血管危险因素的以血压计为基础的人群中选择，接受家庭血压监测，并评估其血压水平和SD、变异系数和平均真实的变异性作为收缩压变异性指标。我们分析了2115例无心力衰竭的患者，并将其分为baPWV较低（= 1800 cm/s，n=651）组。baPWV较高组的SDSBP、CVSBP、ARV（SBP）值和NT-proBNP水平均显著高于baPWV较低组（均P
Increased blood pressure (BP) variability, an index of hemodynamic stress, leads to cardiac overload and worse cardiovascular prognosis. The association between day-by-day home BP variability and NT-proBNP (N-terminal pro-B-type natriuretic peptide) as an index of cardiac overload may be amplified by increased arterial stiffness as assessed by brachial-ankle pulse wave velocity (baPWV). J-HOP (Japan Morning Surge-Home Blood Pressure) Study participants who were selected from a practitioner-based population with at least one cardiovascular risk factor underwent home BP monitoring, and their BP levels and SD, coefficient of variation, and average real variability as indexes of systolic BP variability were assessed. We analyzed 2115 individuals without prevalent heart failure and divided them into lower (= 1800 cm/s, n=651) baPWV groups. The higher baPWV group had significantly higher SDSBP, CVSBP, ARV(SBP) values, and NT-proBNP levels than the lower baPWV group (all P