Enkephalin and fear-motivated behavior.
Enkephalin and fear-motivated behavior.
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脑啡肽和恐惧引发的行为。
DOI：
10.1073/pnas.77.6.3729
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发表时间：
1980
影响因子：
11.1
通讯作者：
J. D. McGaugh
中科院分区：
文献类型：
--
作者：
H. Rigter;R. A. Jensen;J. L. Martínez;R. Messing;B. Vasquez;K. Liang;J. D. McGaugh
在对大鼠进行厌恶性动机任务训练前5分钟，腹腔注射Leu[脑啡肽（400.0 μ g/kg）和脑啡肽类似物[DAla，DLeu]脑啡肽（0.4，4.0和40.0 μ g/kg）。这些肽损害了单向主动回避反应的获得，促进了抑制性回避反应的获得，并且对游泳逃避反应的获得没有影响。这些数据表明，脑啡肽的作用不是通过对运动活动、疼痛感知或反应性或光敏感性的作用来介导的。相反，我们认为[Leu]脑啡肽及其类似物加强了大鼠在先前与厌恶刺激相关的线索存在下抑制行为的倾向。这种效应可能是由于脑啡肽引起的恐惧或觉醒的增加。在低剂量下获得脑啡肽对行为的影响，并在给药后几分钟内观察到。这些发现与脑啡肽作用可能在外周部位启动的解释一致。
Leu[Enkephalin (400.0 micrograms/kg) and the enkephalin analog [DAla,DLeu]enkephalin (0.4, 4.0, and 40.0 micrograms/kg) were intraperitoneally administered to rats 5 min before they were trained on aversively motivated tasks. The peptides impaired acquisition of a one-way active avoidance response, facilitated acquisition of an inhibitory avoidance response, and had no effect on acquisition of a swim-escape response. The data indicate that the enkephalin effects are not mediated through actions on locomotor activity, pain perception or reactivity, or light sensitivity. Rather, we suggest that [Leu]enkephalin and its analog strengthen the tendency of rats to suppress behavior in the presence of cues previously associated with aversive stimulation. This effect may be due to an enkephalin-induced increase in fear or arousal. The enkephalin effect on behavior was obtained at low doses and was observed within a few minutes after administration. These findings are consistent with the interpretation that enkephalin effects may be initiated at a peripheral site.