Quantitative and qualitative alterations of acute-phase protein in healthy elderly persons
Quantitative and qualitative alterations of acute-phase protein in healthy elderly persons
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DOI：
10.1093/ageing/25.3.224
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发表时间：
1996-05-01
期刊：
影响因子：
6.7
通讯作者：
Kushner, I
中科院分区：
文献类型：
--
作者：
Ballou, SP;Lozanski, GB;Kushner, I
为了评估急性时相蛋白与衰老的关系，我们测定了C反应蛋白（CRP）、血清淀粉样蛋白A蛋白（SAA）、α-1酸性糖蛋白（AGP）和糖基化微异质性的血清浓度。对131名独立生活在社区的健康老年人（年龄大于或等于65岁）和47名健康年轻人的AGP进行了研究。老年人的CRP浓度（中位数= 3.0 μ g/ml）显著高于年轻组（中位数= 0.9 μ g/ml，p = 0.0003）。SAA和AGP的浓度在两组中相似，但AGP糖基化形式与伴刀豆球蛋白-A的结合亲和力降低（在慢性炎症状态中观察到的变化）在老年样品中增加（p < 0.0001）。这些发现表明，急性期蛋白质的数量和质量的变化发生在人类的生理老化。
To assess acute-phase proteins in relation to ageing, we measured serum concentrations of C-reactive protein (CRP), serum amyloid-A protein (SAA), alpha-1 acid glycoprotein (AGP) and glycosylation microheterogeneity. of AGP in 131 healthy elderly individuals (aged greater than or equal to 65 years) living independently in the community, and 47 healthy younger individuals. Concentrations of CRP in the older persons (median = 3.0 mu g/ml) were significantly greater than in the younger group (median = 0.9 mu g/ml, p = 0.0003). Concentrations of SAA and AGP were similar in the two groups, but AGP glycosylation forms with reduced binding affinity for concanavalin-A (changes that have been observed in chronic inflammatory states) were increased in the elderly sample (p < 0.0001). These findings suggest that both quantitative and qualitative alterations of acute-phase proteins occur with physiological ageing in humans.