[Roles of histamine in the pathogenesis of bronchial asthma and reevaluation of the clinical usefulness of antihistamines].
[Roles of histamine in the pathogenesis of bronchial asthma and reevaluation of the clinical usefulness of antihistamines].
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DOI：
10.1248/yakushi.131.185
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发表时间：
2011-02
期刊：
影响因子：
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通讯作者：
K. Yamauchi;T. Shikanai;Yutaka Nakamura;Hitoshi Kobayashi;M. Ogasawara;K. Maeyama
中科院分区：
文献类型：
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作者：
K. Yamauchi;T. Shikanai;Yutaka Nakamura;Hitoshi Kobayashi;M. Ogasawara;K. Maeyama
组胺在支气管哮喘的发病机制中起重要作用。然而，H1受体阻滞剂不推荐作为指南中哮喘治疗的首选药物。组胺可能通过免疫细胞（包括T淋巴细胞和树突状细胞）中的H1受体（H1 R）、H2 R和H4 R在过敏性气道炎症中发挥各种作用。因此，我们使用组胺缺乏小鼠评估其在过敏性气道炎症中的作用。提示组胺对杯状细胞增生有一定的预防作用。有机阳离子转运蛋白-3（OCT-3）被认为是组胺的转运蛋白。OCT-3基因R120 R（T/C）多态性与哮喘严重程度相关。最近，有人提出哮喘和过敏性鼻炎应作为单一的气道疾病进行治疗。哮喘和过敏性鼻炎的合并症非常高（70-80%），并且它们具有相似的过敏性炎症。H1受体阻滞剂被推荐为治疗过敏性鼻炎的一线药物。因此，强烈建议哮喘和过敏性鼻炎患者使用H1受体阻滞剂。
Histamine has been reported to play an important role in pathogenesis of bronchial asthma. However, H1-blockers are not recommended as the first drug for asthma therapy in the guidelines. Histamine may play various roles in allergic airway inflammation through the H1 receptor (H1R), H2R, and H4R in immune cells including T lymphocytes and dendritic cells. We therefore evaluated its role in allergic airway inflammation with the use of histamine-deficient mice. The results suggested that histamine plays a role in the prevention of goblet cell hyperplasia. Organic cation transporter-3 (OCT-3) is thought to be a transporter of histamine. Polymorphism of OCT-3 {R120R (T/C)} was associated with the severity of asthma. Recently, it has been proposed that both asthma and allergic rhinitis should be treated as a single airway disease. Comorbidity of asthma and allergic rhinitis is very high (70-80%) and they share similar allergic inflammation. H1-blockers are recommended as first-line drugs to treat allergic rhinitis in the guidelines. Therefore H1-blockers are strongly recommended for patients with both asthma and allergic rhinitis.