Bilateral diffuse uveal melanocytic proliferation in a patient with cancer-associated retinopathy
Bilateral diffuse uveal melanocytic proliferation in a patient with cancer-associated retinopathy
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DOI：
10.1016/j.ajo.2005.05.048
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发表时间：
2005-11-01
影响因子：
4.2
通讯作者：
Ohno, S
中科院分区：
文献类型：
--
作者：
Saito, W;Kase, S;Ohno, S
目的：描述一例双眼弥漫性葡萄膜黑素细胞增生症(BDUMP)合并癌症相关视网膜病变(CAR)的患者。设计：干预性病例报告。方法：一位66岁女性患者在全子宫切除术后4个月出现进行性视力丧失。眼科检查，血清和房水免疫印迹试验，癌细胞免疫组织化学检测。结果：检测发现BDUMP和严重的视网膜功能障碍。检测血清中抗恢复素和热休克相关蛋白70(HSC 70)的自身抗体。结论：BDUMP和CAR同时发生的病例并不多见。恢复素和HSC 70的异常表达触发了血清自身抗体的产生，从而导致光感受器退化。
PURPOSE: To describe a patient with bilateral diffuse uveal melanocytic proliferation (BDUMP) and cancer-associated retinopathy (CAR).DESIGN: Interventional case report.METHODS: A 66-year-old woman developed progressive vision loss 4 months after total hysterectomy. Ophthalmologic examination, Western blot test of sera and aqueous humor, and immunohistochemistry of carcinoma cells were performed.RESULTS: Testing revealed BDUMP and severe retinal dysfunction. Autoantibodies against recoverin and heat shock cognate protein 70 (hsc 70) were detected in serum. Cytoplasmic immunoreactivity for recoverin and hsc 70 was observed in endometrioid carcinoma cells.CONCLUSIONS: Simultaneous cases of BDUMP and CAR are rare. Aberrantly expressed recoverin and hsc 70 triggered serum autoantibody production, which caused photoreceptor degeneration.