On the PAM matrix model of protein evolution.
On the PAM matrix model of protein evolution.
复制标题
蛋白质进化的PAM矩阵模型。
DOI：
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发表时间：
1985
影响因子：
10.7
通讯作者：
W. Wilbur
中科院分区：
文献类型：
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作者：
W. Wilbur
研究了蛋白质进化的PAM矩阵模型的内部一致性。1 PAM矩阵已从密切相关序列中观察到的氨基酸置换构建。这种替换有两种类型，不需要中间氨基酸替换的那些和需要中间氨基酸替换的那些。第二种类型的替代通常必须通过第一种类型的重复来产生。这允许在预测第二类型的数据时使用第一类型的数据，使得1PAM矩阵的一些元素可以用于预测其他元素。一个超过两个数量级的差异被发现之间的预测和数据进行时。这在一定程度上是由于构建矩阵时的错误造成的。然而，似乎也有必要修改基本模式。考虑了几种可能性。其中之一是纳入与每个氨基酸相关的位点依赖性可变性谱。
The internal consistency of the PAM matrix model of protein evolution is here investigated. The 1 PAM matrix has been constructed from amino acid replacements observed in closely related sequences. Such replacements are of two types, those that do not require an intermediate amino acid replacement and those that do. The second type of replacement must generally be produced by a repetition of the first. This allows data on the first type to be used in predicting data on the second type so that some elements of the 1 PAM matrix may be used to predict others. A discrepancy of more than two orders of magnitude is found between the predictions and the data when this is carried out. This is partly accounted for by an error in constructing the matrix. However, it also seems necessary that the basic model be modified. Several possibilities are considered. One of these is to incorporate a site-dependent spectrum of mutabilities associated with each amino acid.