Clinical Applications of Hybrid PET/MRI in Neuroimaging
Clinical Applications of Hybrid PET/MRI in Neuroimaging
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DOI：
10.1097/rlu.0b013e3182638ea6
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发表时间：
2013-01-01
影响因子：
10.6
通讯作者：
Vargas, Maria-Isabel
中科院分区：
文献类型：
--
作者：
Garibotto, Valentina;Heinzer, Susanne;Vargas, Maria-Isabel
目的：应用新型全身混合式PET/MR扫描仪对15例患者[男性6例，女性9例；平均年龄51(30)岁；年龄范围6~89岁]进行联合成像检查。两种方法的标准成像方案采用“头部线圈”和增强后的全诊断MR方案。通过对磁共振图像进行组织分割，并结合线圈和体表的衰减模板，对PET图像进行衰减校正。临床指征包括：疑似神经退行性疾病患者的认知障碍、药物难治性癫痫的术前评估和脑肿瘤分期。结果：所有病例(4例神经退行性疾病患者，6例癫痫患者，5例高级别肿瘤患者)均获得了完全的诊断质量，检查总持续时间保持在可容忍的范围内(P<0.05)。
Purpose: We tested the performance and clinical applicability of combined protocols for brain imaging studies acquired on a new whole-body hybrid PET/MR scanner.Patients and Methods: Fifteen patients [6 male and 9 female patients; mean (SD) age, 51 (30) y; range, 6-89 y] were scanned on a Philips Ingenuity TF PET/MR. Standard imaging protocols of both modalities were combined, using a "head coil" and contrast-enhanced fully diagnostic MR protocols. Attenuation correction of the PET images was performed using tissue segmentation of the MR image and incorporation of attenuation templates measured for coils and table.The clinical indications evaluated are as follows: patients with cognitive disturbance of suspected neurodegenerative origin, presurgical evaluation of drug-refractory epilepsy, and brain tumor staging. For the first 2 indications, FDG PET imaging was performed, whereas for the last, fluoroethyltyrosine, an amino acid tracer, was used.Results: In all cases (4 patients with neurodegenerative disease, 6 patients with epilepsy, and 5 patients with high-grade tumor), we obtained full diagnostic quality of both modalities and the total duration of the examination remained within a tolerable range (