Oral Health and Cancer.
Oral Health and Cancer.
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DOI：
10.1007/s40496-019-0213-7
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发表时间：
2019-06-01
影响因子：
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通讯作者：
Michaud, Dominique S
中科院分区：
文献类型：
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作者：
Chung, Mei;York, Benjamin R;Michaud, Dominique S
综述目的：最近发表的研究为口腔健康对癌症风险的作用提供了新的证据。这篇综述总结了关于这一主题的最新研究，包括几个新的队列研究，研究了牙周病和癌症risk.Recent Findings的协会：最一致的结果与牙周病的协会已被观察到肺癌，五出7项研究报告统计学显着增加肺癌的风险。对于胰腺癌、结直肠癌和头颈部癌，研究之间的相关性不太一致，总体相对风险估计值没有统计学意义。然而，考虑到现有数据的局限性（即，牙周病评估中的测量误差和小样本量），以及越来越多的人支持以前与牙周病相关的细菌如何在致癌作用中发挥作用的生物学机制。牙周病的治疗和预防可能成为重要的有针对性的癌症预防策略。
PURPOSE OF REVIEW: Recently published studies have provided new evidence for a role of oral health on risk of cancer. This review summarizes the latest research on this topic, including several new cohort studies that have examined associations on periodontal disease and cancer risk.RECENT FINDINGS: The most consistent findings for associations with periodontal disease have been observed for lung cancer; five out of seven studies have reported statistically significant increases in risk of lung cancer. For pancreatic, colorectal and head and neck cancers, the associations are less consistent across studies, and the overall summary relative risk estimates are not statistically significant. However, these associations remain of interest, given the limitations of existing data (i.e., measurement error in periodontal disease assessment and small sample sizes), and growing support for biological mechanisms on how bacteria previously linked to periodontal disease may play a role in carcinogenesis.SUMMARY: Future studies need improved assessment of periodontal disease in population- based studies to determine if heterogeneity of current studies resides with measurement error. Periodontal disease treatment and prevention may turn out to be important targetable cancer prevention strategies.