Constructing core-shell structured BaTiO3@carbon boosts piezoelectric activity and cell response of polymer scaffolds
Constructing core-shell structured BaTiO3@carbon boosts piezoelectric activity and cell response of polymer scaffolds
复制标题
构建核壳结构BaTiO3@carbon可增强聚合物支架的压电活性和细胞响应
DOI：
10.1016/j.msec.2021.112129
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发表时间：
2021-04-26
影响因子：
7.9
通讯作者：
Shuai, Cijun
中科院分区：
文献类型：
--
作者：
Qi, Fangwei;Zeng, Zichao;Shuai, Cijun
压电复合材料结合了聚合物的柔韧性和陶瓷的压电系数，在构建骨愈合微环境方面显示出巨大的潜力。本文采用原位氧化自聚合和模板碳化的方法制备了具有核壳结构的BaTiO_3@C(BT@C)杂化纳米粒子。然后将BT@C引入到选择性激光烧结聚偏氟乙烯(PVDF)支架中。一方面，碳壳作为扩散层为电荷转移和积累提供了空间，在极化过程中可以增强Bt上的局部电场。在这种情况下，BT内部更多的电畴将沿着极化电场方向排列，从而促进BT的压电性。另一方面，由于碳壳中的sp2杂化碳原子与PVDF链中的氢原子形成静电相互作用，从而诱导β相的形成，从而进一步增强了支架的压电响应。结果表明，该支架的输出电压为5.7V，电流为79.8nA，具有较好的压电性能。改进后的电信号有效地促进了细胞的增殖和分化。此外，由于刚性颗粒的强化作用，支架的力学性能也得到了改善。
Piezoelectric composites have shown great potential in constructing electrical microenvironment for bone healing since their integration of polymer flexibility and ceramic piezoelectric coefficient. Herein, core-shell structured BaTiO3@carbon (BT@C) hybrid nanoparticles were prepared by in situ oxidative selfpolymerization and template carbonization. Then the BT@C was introduced into polyvinylidene fluoride (PVDF) scaffolds manufactured by selective laser sintering. On one hand, the carbon shell could strengthen the local electric field loaded on BT in poling process owing to it served as a diffusion layer to provide space for charge transfer and accumulation. In this case, more electric domain within BT would be aligned along the polarization field direction and thus promoted the paly of BT's piezoelectric activity. On the other hand, the carbon shell could induce the formation of beta phase due to the sp2 hybrid-bonded carbon atoms in carbon shell forming electrostatic interaction with hydrogen atoms in PVDF chains, which further enhanced the piezoelectric response of the scaffolds. Results showed that the scaffold presented augmented piezoelectric performance with output voltage of 5.7 V and current of 79.8 nA. The improved electrical signals effectively accelerated cell proliferation and differentiation. Furthermore, the scaffold displayed improved mechanical performance due to rigid particle strengthen effect.