Reversible inhibition by interferons alpha and beta of 125I incorporation and thyroid hormone release by human thyroid follicles in vitro.
Reversible inhibition by interferons alpha and beta of 125I incorporation and thyroid hormone release by human thyroid follicles in vitro.
复制标题
体外干扰素 α 和 β 对 125I 掺入和人甲状腺滤泡释放甲状腺激素的可逆抑制。
DOI：
10.1210/jcem.77.5.8077347
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Kanji Sato
中科院分区：
文献类型：
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作者：
K. Yamazaki;Y. Kanaji;Kazuo Shizume;Y. Yamakawa;Hiroshi Demura;Takao Obara;Kanji Sato
当干扰素（IFN-α-2a，IFN-α-2b，天然IFN-α和IFN-β）与人甲状腺滤泡一起培养时，每种IFN均以浓度依赖性方式抑制TSH诱导的甲状腺功能（125 I掺入和125 I-T4释放）。在1-10 U/ml时产生最小抑制作用。然而，抑制作用是可逆的，当在12 h内从培养基中去除IFN时，未检测到抑制作用。这些体外研究结果表明，每种IFN在临床可达到的水平直接抑制人甲状腺功能。然而，由于这种抑制作用是可逆的，IFN治疗在大多数没有预先存在的甲状腺自身免疫的患者中只会引起轻微的甲状腺功能障碍。
When interferons (IFN-alpha-2a, IFN-alpha-2b, natural IFN-alpha and IFN-beta) were cultured with human thyroid follicles, each IFN inhibited TSH-induced thyroid function (125I incorporation and release of 125I-T4) in a concentration-dependent manner. The minimal inhibitory effect was exerted at 1-10 U/ml. However, the inhibitory effect was reversible, and no inhibitory effect was detected when IFNs were removed from the medium within 12 h. These in vitro findings suggest that each IFN directly inhibits human thyroid function at clinically attainable levels. However, since the inhibitory effect was reversible, IFN therapy would provoke only subtle thyroid dysfunction in a majority of patients without preexisting thyroid autoimmunity.