Leptin applications in 2015: what have we learned about leptin and obesity?
Leptin applications in 2015: what have we learned about leptin and obesity?
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2015年的瘦素应用：我们对瘦素和肥胖症学到了什么？
DOI：
10.1097/med.0000000000000184
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发表时间：
2015-10
期刊：
影响因子：
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通讯作者：
Mantzoros CS
中科院分区：
文献类型：
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作者：
Farr OM;Gavrieli A;Mantzoros CS
为了总结以往和当前瘦素治疗的进展，我们描述了瘦素如何在瘦素缺乏状态（如最近被批准的脂肪营养不良）中发挥作用，以及它如何在未来对典型肥胖有用。1994年瘦素的发现为理解肥胖的病理生理学和治疗奠定了基础。瘦素治疗逆转与先天性瘦素缺乏相关的病态肥胖，似乎有效地治疗脂肪营养不良，这一发现导致瘦素在美国和日本被批准用于治疗脂肪营养不良。另一方面，典型的肥胖以高瘦素血症和瘦素抵抗为特征。因此，瘦素治疗已被证明对单独减肥无效，但与其他疗法联合使用或维持减肥效果可能有用。瘦素还不能治疗典型的肥胖，然而，它对逆转瘦素缺乏引起的肥胖和脂肪营养不良是有效的。瘦素抵抗的新机制和途径不断被发现，而新技术和药物组合的发展可能会提高瘦素的疗效和安全性，使其成为治疗典型肥胖的有效方法。
To summarize previous and current advancements for leptin therapeutics, we described how leptin may be useful in leptin deficient states such as lipodystrophy, for which leptin was recently approved, and how it may be useful in the future for typical obesity. The discovery of leptin in 1994 built the foundation for understanding the pathophysiology and treatment of obesity. Leptin therapy reverses morbid obesity related to congenital leptin deficiency and appears to effectively treat lipodystrophy, a finding which has led to the approval of leptin for the treatment of lipodystrophy in the USA and Japan. Typical obesity, on the other hand, is characterized by hyperleptinemia and leptin resistance. Thus, leptin administration has proven ineffective for inducing weight loss on its own but may be useful in combination with other therapies or for weight loss maintenance. Leptin is not yet able to treat typical obesity, however, it is effective for reversing leptin deficiency-induced obesity and lipodystrophy. New mechanisms and pathways involved in leptin resistance are continuously discovered, while the development of new techniques and drug combinations which may improve leptin’s efficacy and safety regenerate the hope for its use as an effective treatment for typical obesity.