Role of free radicals and antioxidant status in childhood nephrotic syndrome.
Role of free radicals and antioxidant status in childhood nephrotic syndrome.
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DOI：
10.4103/0971-4065.78062
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发表时间：
2011-01-01
影响因子：
0.8
通讯作者：
Katta, A V
中科院分区：
文献类型：
--
作者：
Ghodake, S R;Suryakar, A N;Katta, A V
肾病综合征（NS）以大量蛋白尿和低蛋白尿为特征。活性氧在NS蛋白尿的发病机制中起重要作用。本研究旨在通过检测NS患儿体内氧化剂和抗氧化剂水平，探讨活性氧在NS发病机制中的作用。选择30例NS患者和30例年龄、性别匹配的健康受试者进行研究。与健康对照组相比，肾病患者血清过氧化脂质水平显著升高，而一氧化氮水平、红细胞超氧化物歧化酶活性、维生素C水平、白蛋白和总抗氧化能力显著降低。与对照组相比，NS患儿的尿酸和胆红素水平显著升高。患者与对照组之间维生素E水平无显著差异。结论：NS蛋白尿的发生与ROS生成增加和抗氧化防御功能下降有关。
Nephrotic syndrome (NS) is characterized by heavy proteinuria and hypoalbuminuria. Reactive oxygen species (ROS) seem to play an important role in the etiopathogenesis of proteinuria in NS. This study aims to evaluate the potential role of reactive oxygen species in pathogenesis of NS by estimating the levels of oxidants and antioxidants in children with NS. Thirty patients of NS and thirty age, sex-matched healthy subjects, were selected for the study. As compared to healthy controls, the levels of serum lipid peroxide were significantly elevated while levels of nitric oxide, erythrocyte-superoxide dismutase activity, levels of vitamin C, albumin and total antioxidant capacity were significantly reduced in nephrotic patients. The levels of uric acid and bilirubin were significantly increased in children with NS as compared to controls. There was no significant difference in vitamin E level between patients and controls. It can be concluded that increased ROS generation and decreased antioxidant defense may be related to the pathogenesis of proteinuria in NS.