Dopamine antagonists during parturition disrupt maternal care and the retention of maternal behavior in rats
Dopamine antagonists during parturition disrupt maternal care and the retention of maternal behavior in rats
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DOI：
10.1016/s0091-3057(02)00941-3
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发表时间：
2002-11-01
影响因子：
3.6
通讯作者：
Bridges, RS
中科院分区：
文献类型：
--
作者：
Byrnes, EM;Rigero, BA;Bridges, RS
在分娩时与幼鼠的短暂接触使雌性大鼠能够建立并保留完整的母性行为，使其能够在未来对幼鼠迅速做出反应。为了确定多巴胺系统是否参与母体行为的保留，在围产期期间向雌性动物连续输注多巴胺拮抗剂，然后允许与幼仔进行短暂的相互作用（3 h）或不与幼仔进行相互作用（幼仔出生时取出）。雌性动物暴露于D1样拮抗剂SCH 23390（0.1或1.0 mg/kg/天）或D2样拮抗剂氯波必利（0.5或1.0 mg/kg/天）。高剂量的任一DA拮抗剂导致产后立即对产妇护理的显着衰减。然而，当7天后检测母性行为保留时，仅暴露于D2拮抗剂的雌性动物显示出对供体幼仔的完全母性行为（FMB）的延迟反应。因此，虽然这两种多巴胺受体亚型出现必要的产妇的行为在产后早期的充分和快速的表达，只有D2受体亚型似乎参与保留这种行为。(C)2002年爱思唯尔科技有限公司All rights reserved.
Brief contact with pups at parturition enables the female rat to establish and retain the full repertoire of maternal behaviors, allowing her to respond rapidly to pups in the future. To determine whether the dopamine system is involved in the retention of maternal behavior, females were continuously infused with dopamine antagonists during the periparturitional period and then allowed either a brief interaction period with pups (3 h) or no interaction with pups (pups removed as they were born). Females were exposed to either the D1-like antagonist SCH 23390 (0.1 or 1.0 mg/kg/day) or the D2-like antagonist clebopride (0.5 or 1.0 mg/kg/day). The high dose of either DA antagonist resulted in significant attenuation of maternal care immediately postpartum. When tested for the retention of maternal behavior 7 days later, however, only the females exposed to the D2 antagonist displayed a delayed response to shown full maternal behavior (FMB) towards donor pups. Thus, while both dopamine receptor subtypes appear necessary for the full and rapid expression of maternal behavior during the early postpartum period, only the D2 receptor subtype appears to be involved in the retention of this behavior. (C) 2002 Elsevier Science Inc. All rights reserved.