Peripheral ER structure and function.

Peripheral ER structure and function.
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DOI:
10.1016/j.ceb.2009.04.004
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发表时间:
2009-08
影响因子:
7.5
通讯作者:
Voeltz GK
Voeltz GK
中科院分区:
生物学2区
文献类型:
--
作者:
English AR;Zurek N;Voeltz GK

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内质网(ER)是一个单一的连续膜封闭的细胞器,由功能和结构不同的领域。ER结构域包括核被膜(NE)和外周ER,外周ER是遍布细胞质的小管和片的网络。ER的结构组织与其许多不同的细胞功能有关。在这里,我们将讨论如何组织成结构上不同的结构域,存在于整个细胞周期的连续膜双层内的外周ER的各种功能域。此外,我们将总结我们目前的知识,外周ER膜如何接触细胞质的其他区域,包括细胞骨架,线粒体,高尔基体,质膜和什么是已知的这些相互作用的功能。
The endoplasmic reticulum (ER) is a single continuous membrane-enclosed organelle made up of functionally and structurally distinct domains. The ER domains include the nuclear envelope (NE) and the peripheral ER, which is a network of tubules and sheets spread throughout the cytoplasm. The structural organization of the ER is related to its many different cellular functions. Here we will discuss how the various functional domains of the peripheral ER are organized into structurally distinct domains that exist within the continuous membrane bilayer throughout the cell cycle. In addition, we will summarize our current knowledge on how peripheral ER membranes contact various other regions of the cytoplasm including the cytoskeleton, mitochondria, Golgi, and the plasma membrane and what is known about the functions of these interactions.
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