Room temperature intramolecular hydro-O-alkylation of aldehydes:: sp3 C-H functionalization via a Lewis acid catalyzed tandem 1,5-hydride transfer/cyclization
Room temperature intramolecular hydro-O-alkylation of aldehydes:: sp3 C-H functionalization via a Lewis acid catalyzed tandem 1,5-hydride transfer/cyclization
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DOI：
10.1021/ol0522283
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发表时间：
2005-11-24
期刊：
影响因子：
5.2
通讯作者：
Sames, D
中科院分区：
文献类型：
--
作者：
Pastine, SJ;Sames, D
The scope and limitations of intramolecular hydro-O-alkylation of aldehyde substrates leading to spiroketals and bicyclic ketals and aminals is reported. The direct transformation of tertiary and sterically hindered secondary sp(3) C-H bonds into C-O bonds under the action of a catalytic amount of a variety of Lewis acids is described. The mechanism of these transformations is proposed to involve a tandem hydride transfer/cyclization sequence.
