Normal macular thickness measurements in healthy eyes using stratus optical coherence tomography
Normal macular thickness measurements in healthy eyes using stratus optical coherence tomography
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DOI：
10.1001/archopht.124.2.193
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发表时间：
2006-02-01
影响因子：
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通讯作者：
Schuman, JS
中科院分区：
文献类型：
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作者：
Chan, A;Duker, JS;Schuman, JS
目的：使用Stratus OCT（OCT3）最新商业可用的光学相干断层扫描（OCT）成像软件3.0版报告健康眼睛的正常黄斑厚度测量值。
方法：37名健康受试者的37只眼睛接受了全面的眼科检查，包括OCT检查。使用OCT3获取6条长度为6毫米且以中心凹为中心的放射状扫描图像。视网膜厚度由OCT成像软件自动计算。测量值以早期糖尿病视网膜病变研究中定义的9个区域中每个区域的平均值和标准差显示。
结果：OCT3上的中心凹厚度（直径1000μm的中心区域的平均厚度）和中心中心凹厚度（6条放射状扫描交叉点的平均厚度）分别为212±20μm和182±23μm。黄斑厚度测量值在中心凹中心最薄，在中心3毫米直径范围内最厚，并向黄斑周边逐渐变薄。颞侧象限比鼻侧象限薄。手动测定的中心中心凹厚度为170±18μm，比从OCT3软件自动获得的值大约少12μm。年龄与中心凹厚度之间无相关性（P = 0.80）。
结论：平均中心凹厚度测量值比先前报道的值厚38 - 62μm，而平均中心中心凹厚度测量值比先前发表的值厚20 - 49μm。在解读OCT扫描结果时应考虑到这种差异。
Objective: To report normal macular thickness measurements in healthy eyes using the latest commercially available optical coherence tomography (OCT) mapping software, version 3.0, from the Stratus OCT (OCT3).Methods: Thirty-seven eyes from 37 healthy subjects underwent a complete ophthalmologic examination, including OCT. Six radial scans, 6 mm in length and centered on the fovea, were obtained using the OCT3. Retinal thickness was automatically calculated by OCT mapping software. Measurements were displayed as the mean and standard deviation for each of the 9 regions defined in the Early Treatment Diabetic Retinopathy Study.Results: Foveal thickness (mean thickness in the central 1000-mu m diameter area) and central foveal thickness (mean thickness at the point of intersection of 6 radial scans) on the OCT3 were 212 +/- 20 and 182 +/- 23 mu m, respectively. Macular thickness measurements were thinnest at the center of the fovea, thickest within 3-mm diameter of the center, and diminished toward the periphery of the macula. The temporal quadrant was thinner than the nasal quadrant. Central foveal thickness was also manually determined as 170 +/- 18 mu m, approximately 12 mu m less than the value automatically obtained from the OCT3 software. There was no correlation between age and foveal thickness (P=.80).Conclusions: Mean foveal thickness measurements were 38 to 62 mu m thicker than previously reported values, while mean central foveal thickness measurements were 20 to 49 mu m thicker than previously published values. This discrepancy should be considered when interpreting OCT scans.