Gradient nonlinearity correction to improve apparent diffusion coefficient accuracy and standardization in the american college of radiology imaging network 6698 breast cancer trial.
Gradient nonlinearity correction to improve apparent diffusion coefficient accuracy and standardization in the american college of radiology imaging network 6698 breast cancer trial.
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DOI：
10.1002/jmri.24883
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Hylton N
中科院分区：
文献类型：
--
作者：
Newitt DC;Tan ET;Wilmes LJ;Chenevert TL;Kornak J;Marinelli L;Hylton N
为了评估多中心乳腺癌治疗反应研究中幻影和人体受试者弥散加权（DW）磁共振成像（MRI）扫描定量表观扩散系数（ADC）测量的梯度非线性校正（GNC）程序，采用五阶球面谐波梯度建模的GNC程序，回顾性地对幻影和人体受试者扫描进行了定性。已知扩散系数的冰水幻影在五个不同的研究中心用不同的扫描仪和接收器线圈进行扫描。人体体内数据包括来自四个地点的54名患者的基线和早期治疗检查。使用和不使用GNC生成ADC地图。定义了感兴趣的区域，以量化GNC在乳房成像位置上的绝对误差和变化。幻影ADC误差随感兴趣区域（ROI）位置和扫描仪配置而变化；配置的平均误差在1.4%到19.9%之间。GNC显著降低了所有站点的总体平均误差，从9.9%降至0.6% （P = 0.016）。GNC的空间依赖性在左右（RL）和前后（AP）方向最大。GNC在不同部位使人类受试者平均肿瘤ADC降低0.2 - 12%。通过回归，在基线和随访期间，肿瘤ROI位置每变化1厘米，ADC早期治疗反应测量的估计变化为2.4%。GNC对于消除乳腺DWI定量中较大的系统相关误差是有效的。GNC在确保多中心研究的可重复性和减少因就诊之间肿瘤位置的空间变化而引起的纵向治疗反应测量误差方面可能很重要。
To evaluate a gradient nonlinearity correction (GNC) program for quantitative apparent diffusion coefficient (ADC) measurements on phantom and human subject diffusion-weighted (DW) magnetic resonance imaging (MRI) scans in a multicenter breast cancer treatment response study A GNC program using fifth-order spherical harmonics for gradient modeling was applied retrospectively to qualification phantom and human subject scans. Ice-water phantoms of known diffusion coefficient were scanned at five different study centers with different scanners and receiver coils. Human in vivo data consisted of baseline and early-treatment exams on 54 patients from four sites. ADC maps were generated with and without GNC. Regions of interest were defined to quantify absolute errors and changes with GNC over breast imaging positions. Phantom ADC errors varied with region of interest (ROI) position and scanner configuration; the mean error by configuration ranged from 1.4% to 19.9%. GNC significantly reduced the overall mean error for all sites from 9.9% to 0.6% (P = 0.016). Spatial dependence of GNC was highest in the right-left (RL) and anterior-posterior (AP) directions. Human subject mean tumor ADC was reduced 0.2 to 12% by GNC at different sites. By regression, every 1-cm change in tumor ROI position between baseline and follow-up visits resulted in an estimated change of 2.4% in the ADC early-treatment response measurement. GNC is effective for removing large, system-dependent errors in quantitative breast DWI. GNC may be important in ensuring reproducibility in multicenter studies and in reducing errors in longitudinal treatment response measures arising from spatial variations in tumor position between visits.