Thyroid cancer in children and adolescents--consequences in later life.
Thyroid cancer in children and adolescents--consequences in later life.
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儿童和青少年的甲状腺癌——对以后生活的影响。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
Wiersinga Wm
中科院分区：
文献类型：
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作者：
Wiersinga Wm
甲状腺癌在16岁以下很少见，年发病率为每10万人0.02-0.3例。儿童和青少年时期的甲状腺乳头状癌和滤泡状癌比成人更晚期，这从甲状腺外扩散的频率更高可以看出。复发率也较高。然而，儿童和青少年的生存预后比成人好;为什么如此尚不清楚。据观察，接触切尔诺贝利事故沉降物的儿童，特别是灾难发生时不足1岁的儿童，甲状腺癌发病率增加了约30倍。儿童和青少年甲状腺髓样癌主要作为MEN 2综合征的一部分发生。通过DNA突变分析的早期检测和预防性甲状腺切除术的治疗可导致潜在的正常预期寿命。成年后的后果与甲状腺手术、131 I治疗和TSH抑制剂量的L-T4的长期并发症有关。
Thyroid cancer is rare below the age of 16 years, with an annual incidence of 0.02-0.3 cases per 100,000. Papillary and follicular thyroid cancer in childhood and adolescence is more advanced upon presentation than in adults, as evident from a higher frequency of extra-thyroidal spread. The recurrence rate is also higher. Nevertheless, the prognosis for survival in children and adolescents is better than in adults; why this is so remains unclear. An approximately 30-fold increase in the incidence of thyroid cancer has been observed in children exposed to the fallout of the Chernobyl accident, especially in the age group of <1 year at the time of the disaster. Medullary thyroid cancer in childhood and adolescence occurs mainly as part of the MEN2 syndrome. Early detection by DNA mutation analysis and treatment by prophylactic thyroidectomy results in a potential normal life expectancy. Consequences in adult life relate to long-term complications of thyroid surgery, 131I treatment and TSH-suppressive doses of L-T4.