Low-frequency rTMS over lateral premotor cortex induces lasting changes in regional activation and functional coupling of cortical motor areas
Low-frequency rTMS over lateral premotor cortex induces lasting changes in regional activation and functional coupling of cortical motor areas
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DOI：
10.1016/s1388-2457(03)00063-4
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发表时间：
2003-09-01
影响因子：
4.7
通讯作者：
Shibasaki, H
中科院分区：
文献类型：
--
作者：
Chen, WH;Mima, T;Shibasaki, H
目的：研究0.9Hz重复经颅磁刺激（rTMS）对简单运动任务时大脑运动区神经元活动的影响。方法：在8名受试者中，脑电图（EEG）和肌电图（EMG）在拇指自主收缩过程中，在刺激左侧运动前皮层的0.9 Hz rTMS训练15 min前后同时记录强度为主动运动阈值的90%。通过测量与任务相关的EEG功率和区域间相干性变化以及EEG-EMG相干性（EMGCoh）来评估对皮质运动活动的后效。运动前区皮层的低频rTMS导致（i）α和β波段中与任务相关的功率下降减少，（ii）上α波段中皮层运动区之间与任务相关的连贯性变化选择性增加，和（iii）皮质-肌肉连贯性降低。这些影响持续约15分钟后结束的rTMS intervention.Conclusions：衰减的任务相关的功率变化和减少EMGCoh点到一个持久的抑制自愿激活皮层运动区后rTMS。目前的数据提供了一个短暂的重组运动相关的神经元活动在皮层运动区后0.9 Hz rTMS的premotor cortex.Significance的证据：低频rTMS改变了区域激活和功能耦合的皮层运动区的EEG分析表明。(C)2003年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To study the effect of 0.9 Hz repetitive transcranial magnetic stimulation (rTMS) of the lateral premotor cortex on neuronal activity in cortical motor areas during simple motor tasks.Methods: In 8 subjects, electroencephalogram (EEG) and electromyogram (EMG) were simultaneously recorded during voluntary contractions of the thumb before and after a 15 min train of 0.9 Hz rTMS over the left lateral premotor cortex at stimulus intensity of 90% of active motor threshold. After-effects on cortical motor activity were assessed by measuring the task-related EEG power and inter-regional coherence changes, and the EEG-EMG coherence (EMGCoh).Results: Low-frequency rTMS over the premotor cortex gave rise to (i) a reduction of the task-related power decrease in the alpha and beta bands, (ii) a selective increase in the task-related coherence change among cortical motor areas in the upper alpha band, and (iii) a decrease in the cortico-muscular coherence. These effects lasted about 15 min after the end of rTMS intervention.Conclusions: The attenuated task-related power changes and decreased EMGCoh point to a lasting suppression of voluntary activation of cortical motor areas after rTMS. The present data provide an evidence for a transient reorganization of movement-related neuronal activity in the cortical motor areas after 0.9 Hz rTMS over the premotor cortex.Significance: Low-frequency rTMS changes the regional activation and functional coupling of cortical motor areas as demonstrated by EEG analysis. (C) 2003 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.