Mammographic density in a multiethnic cohort
Mammographic density in a multiethnic cohort
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DOI：
10.1097/gme.0b013e318032569c
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发表时间：
2007-09-01
影响因子：
2.7
通讯作者：
Sternfeld, Barbara
中科院分区：
文献类型：
--
作者：
Habel, Laurel A.;Capra, Angela M.;Sternfeld, Barbara
目的：比较乳腺X线摄影密度在绝经前和早期围绝经期妇女从四个种族/民族群体，并检查密度和文化适应在日本和中国women.Design：这项研究包括391白色，60非洲裔美国人，171日本人和179中国参与者在全国妇女健康的研究，美国妇女过渡到更年期的多地点研究。评估绝经前或围绝经期早期妇女的乳腺X线照片中致密乳腺组织的面积和致密组织占乳腺的百分比（密度百分比）。从标准化工具中获得有关种族/民族、文化适应和其他因素的信息。多元线性回归模型被用来研究种族/民族或文化适应和密度measurements.Results之间的关联：调整后的平均百分比密度最高的中国（52%）和最低的非洲裔美国人（34%）妇女。在对体重指数、绝经状态、头胎年龄、母乳喂养时间、腰围和吸烟进行额外调整后，非裔美国人的平均密度百分比最高（51%），日本妇女最低（39%）。相比之下，非裔美国人的致密组织面积最高，白色、日本和中国女性的致密组织面积相似。文化适应较少的中国和日本妇女往往有较大面积的密度和较高的百分比density.Conclusions：无论是年龄调整，也不完全调整的结果，密度或致密组织的面积反映了目前的差异，乳腺癌的发病率相似年龄的非洲裔美国人，日本人，中国人，和白色妇女。此外，在文化适应度较低的亚洲女性中，乳房X线摄影密度较高。
Objectives: To compare mammographic density among premenopausal and early perimenopausal women from four racial/ethnic groups and to examine density and acculturation among Japanese and Chinese women.Design: The study included 391 white, 60 African American, 171 Japanese, and 179 Chinese participants in the Study of Women's Health Across the Nation, a multisite study of US women transitioning through menopause. Mammograms done when women were premenopausal or early perimenopausal were assessed for area of dense breast tissue and the percent of the breast occupied by dense tissue (percent density). Information on race/ ethnicity, acculturation, and other factors was obtained from standardized instruments. Multiple linear regression modeling was used to examine the association between race/ethnicity or acculturation and density measures.Results: Age-adjusted mean percent density was highest for Chinese (52%) and lowest for African American (34%) women. After additional adjustment for body mass index, menopause status, age at first birth, breast-feeding duration, waist circumference, and smoking, African Americans had the highest mean percent density (51%) and Japanese women had the lowest (39%). In contrast, the area of dense tissue was highest for African Americans and similar for white, Japanese, and Chinese women. Less acculturated Chinese and Japanese women tended to have a larger area of density and a higher percent density.Conclusions: Neither the age-adjusted nor fully adjusted results for percent density or area of dense tissue reflected current differences in breast cancer incidence rates among similarly aged African American, Japanese, Chinese, and white women. In addition, mammographic density was higher in less acculturated Asian women.