Frizzled6 controls hair patterning in mice
Frizzled6 controls hair patterning in mice
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DOI：
10.1073/pnas.0402802101
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发表时间：
2004-06-22
影响因子：
11.1
通讯作者：
Nathans, J
中科院分区：
文献类型：
--
作者：
Guo, N;Hawkins, C;Nathans, J
在包括人类在内的多种哺乳动物物种中发现了毛轮和其他宏观毛发图案。在这里，我们表明，卷曲6（FZ6），一个大家庭的一个成员的完整的膜Writ受体，控制宏观毛发图案的小鼠。Fz6在皮肤和毛囊中表达，并且Fz6基因的靶向缺失在后足上产生定型的轮纹，在头部上产生可变的轮纹和毛簇，以及在躯干上产生毛发的方向错误。胚胎嵌合体实验表明，Fz6的行为，局部控制或传播的宏观毛发图案和上皮细胞，而不是黑色素细胞的来源Fz6依赖的信号。Fz6表型非常类似于果蝇卷曲突变体中观察到的翅毛和刚毛图案缺陷。这些数据意味着，哺乳动物的毛发图案使用类似于果蝇角质层图案的Fz依赖性组织极性系统。
Hair whorls and other macroscopic hair patterns are found in a variety of mammalian species, including humans. We show here that Frizzled6 (Fz6), one member of a large family of integral membrane Writ receptors, controls macroscopic hair patterning in the mouse. Fz6 is expressed in the skin and hair follicles, and targeted deletion of the Fz6 gene produces stereotyped whorls on the hind feet, variable whorls and tufts on the head, and misorientation of hairs on the torso. Embryo chimera experiments imply that Fz6 acts locally to control or propagate the macroscopic hair pattern and that epithelial cells rather than melanocytes are the source of Fz6-dependent signaling. The Fz6 phenotype strongly resembles the wing-hair and bristle patterning defects observed in Drosophila frizzled mutants. These data imply that hair patterning in mammals uses a Fz-dependent tissue polarity system similar to the one that patterns the Drosophila cuticle.