Comparison of Ocular Surface Disease Index and Tear Osmolarity as Markers of Ocular Surface Dysfunction in Video Terminal Display Workers
Comparison of Ocular Surface Disease Index and Tear Osmolarity as Markers of Ocular Surface Dysfunction in Video Terminal Display Workers
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DOI：
10.1016/j.ajo.2014.03.007
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发表时间：
2014-07-01
影响因子：
4.2
通讯作者：
Spinella, Rosaria
中科院分区：
文献类型：
--
作者：
Fenga, Concettina;Aragona, Pasquale;Spinella, Rosaria
目得：比较眼表疾病指数（OSDI）问卷和泪液渗透压，筛选眼表改变在视频显示终端（VDT）users.DESIGN：横断面study.METHODS：64 VDT工人进行筛选眼表改变使用OSDI和泪液渗透压。此外，进行泪膜破裂时间（TBUT）、角膜荧光素染色和睑板腺功能障碍（MGD）评估。这些参数中2个或更多个的改变被认为是眼表功能障碍的迹象。从泪液渗透压评分最差的眼睛获得统计分析数据。主要结果指标为OSDI和泪液渗透压。统计学分析采用受试者工作特征（ROC）曲线和斯皮尔曼相关系数。结果：对于所有考虑的分类变量，泪液渗透压的ROC曲线下面积（AUC）（范围从0.71到0.86）显示，在统计学上显著高于OSDI获得的值（范围从0.51到0.58）（P <0.01）。此外，泪液渗透压与角膜染色和眼表功能障碍呈正相关，与TBUT呈负相关。OSDI和参数considered.CONCLUSIONS之间没有发现相关性：泪液渗透压可以被认为是一个更可靠的测试比OSDI，筛选VDT用户可能的眼表改变时。(Am J Ophthalmol 2014; 158：41-48. (C)2014年，Elsevier Inc.版权所有© 2016
PURPOSE: To compare the Ocular Surface Disease Index (OSDI) questionnaire and tear osmolarity, to screen ocular surface alterations in video display terminal (VDT) users.DESIGN: Cross-sectional study.METHODS: Sixty-four VDT workers were screened for ocular surface alterations using OSDI and tear osmolarity. Furthermore, tear film break-up time (TBUT), fluorescein corneal stain, and assessment for meibomian glands dysfunction (MGD) were carried out. The alteration of 2 or more among these parameters was considered a sign of ocular surface dysfunction. Data for the statistical analysis were obtained from the eyes with the worst tear osmolarity score. Main outcome measures were OSDI and tear osmolarity. For the statistical analysis the receiver operating characteristic (ROC) curves and Spearman correlation coefficient were used. A P < .05 was considered statistically significant.RESULTS: The area under the ROC curve (AUC) for tear osmolarity (ranging from 0.71 to 0.86) showed, for all the classification variables considered, statistically significantly higher values than those obtained with OSDI (ranging from 0.51 to 0.58) (P < .01). Furthermore, tear osmolarity showed a direct correlation with corneal stain and ocular surface dysfunction and an inverse correlation for TBUT. No correlation was found between OSDI and the parameters considered.CONCLUSIONS: Tear osmolarity can be considered a more reliable test than OSDI, when screening VDT users for possible ocular surface alterations. (Am J Ophthalmol 2014; 158:41-48. (C) 2014 by Elsevier Inc. All rights reserved.)