FHL2 (SLIM3) is not essential for cardiac development and function
FHL2 (SLIM3) is not essential for cardiac development and function
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DOI：
10.1128/mcb.20.20.7460-7462.2000
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发表时间：
2000-10-01
影响因子：
5.3
通讯作者：
Chen, J
中科院分区：
文献类型：
--
作者：
Chu, PH;Bardwell, WM;Chen, J
LIM结构域蛋白在脊椎动物的发育和细胞分化中起着重要作用。最近，四个成员和一个半LIM蛋白（FHL）的家庭已被确定和克隆。其中之一，FHL2，在整个发育到成年期的心血管系统中以有限的方式表达，表明FHL2可能在心血管发育和功能中发挥重要作用。在这里，我们描述了代和分析的小鼠携带FHL2基因的无效突变。FHL2缺陷小鼠是可行的，并保持正常的心脏功能之前和之后的急性机械应力诱导的主动脉缩窄。这些数据表明FHL2对心脏发育和功能不是必需的。
LIM domain-containing proteins play critical roles in vertebrate development and cellular differentiation. Recently, four members of the four and one-half LIM protein (FHL) family have been identified and cloned. One of these, FHL2, is expressed in a restricted manner in the cardiovascular system throughout development into adulthood, suggesting that FHL2 may play an important role in cardiovascular development and function. Here we describe the generation and analysis of mice carrying a null mutation of the FHL2 gene. FHL2-deficient mice are viable and maintain normal cardiac function both before and after acute mechanical stress induced by aortic constriction. These data suggest that FHL2 is not essential for cardiac development and function.