Sensory-based and higher-order operations contribute to abnormal emotional prosody processing in schizophrenia: an electrophysiological investigation
Sensory-based and higher-order operations contribute to abnormal emotional prosody processing in schizophrenia: an electrophysiological investigation
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DOI：
10.1017/s003329171200133x
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发表时间：
2013-03-01
影响因子：
6.9
通讯作者：
Niznikiewicz, M. A.
中科院分区：
文献类型：
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作者：
Pinheiro, A. P.;del Re, E.;Niznikiewicz, M. A.
背景精神分裂症的特征是情感韵律（EP）感知的缺陷。然而，目前尚不清楚韵律加工的哪些阶段是异常的，以及语义内容的存在是否有助于异常。本研究旨在探讨15例慢性精神分裂症患者和15例健康对照者的事件相关电位（ERP）的相关性。一名女性说话者共生成了114个具有中性语义内容的句子（具有语义内容（SSC）条件的句子）（38个高兴，38个生气，38个中性语调）。在语义内容不可理解的“纯韵律”句子（PPS）条件下合成并呈现相同的句子。观察到N100和P200振幅的组间差异：患者的特征是SSC的N100更负，愤怒和快乐的SSC和快乐的PPS的P200更正。快乐SSC和PPS的妄想与P200波幅相关。精神分裂症患者EP的错误率也较高：中性SSC的错误率较高，与N100降低有关;愤怒SSC的错误率较高，与P200降低有关。这些结果表明，韵律加工的异常发生在EP加工的三个阶段，并加强在SSC。P200振幅的快乐韵律和妄想之间的相关性表明，在处理情绪显着的声学线索异常可能在精神分裂症精神病学中发挥的作用。ERP和行为数据之间的相关性表明精神分裂症患者早期感觉异常和韵律识别之间的关系。
Background. Schizophrenia is characterized by deficits in emotional prosody (EP) perception. However, it is not clear which stages of processing prosody are abnormal and whether the presence of semantic content contributes to the abnormality. This study aimed to examine event-related potential (ERP) correlates of EP processing in 15 chronic schizophrenia individuals and 15 healthy controls.Method. A total of 114 sentences with neutral semantic content [sentences with semantic content (SSC) condition] were generated by a female speaker (38 with happy, 38 with angry, and 38 with neutral intonation). The same sentences were synthesized and presented in the 'pure prosody' sentences (PPS) condition where semantic content was unintelligible.Results. Group differences were observed for N100 and P200 amplitude : patients were characterized by more negative N100 for SSC, and more positive P200 for angry and happy SSC and happy PPS. Correlations were found between delusions and P200 amplitude for happy SSC and PPS. Higher error rates in the recognition of EP were also observed in schizophrenia : higher error rates in neutral SSC were associated with reduced N100, and higher error rates in angry SSC were associated with reduced P200.Conclusions. These results indicate that abnormalities in prosody processing occur at the three stages of EP processing, and are enhanced in SSC. Correlations between P200 amplitude for happy prosody and delusions suggest a role that abnormalities in the processing of emotionally salient acoustic cues may play in schizophrenia symptomatology. Correlations between ERP and behavioral data point to a relationship between early sensory abnormalities and prosody recognition in schizophrenia.