Mechanotransduction: a major regulator of homeostasis and development
Mechanotransduction: a major regulator of homeostasis and development
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DOI：
10.1002/wsbm.79
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发表时间：
2010-11-01
影响因子：
7.9
通讯作者：
Mofrad, Mohammad R. K.
中科院分区：
文献类型：
--
作者：
Kolahi, Kevin S.;Mofrad, Mohammad R. K.
在生物学的几乎所有方面，力都是生命形式和功能的相关调节器。最近，科学已经确定，细胞对不同大小和时间尺度的力非常敏感，它们将机械刺激转化为化学反应。这种现象，称为机械转导，是细胞生理学的一个组成部分，对生物体的发育有着深远的影响。此外，机械性能或机械力传导功能障碍常常导致生物体的病理学。在这篇综述中，我们描述了机械转导和理论的基础上如何部队可能被认为是从分子到生物体的规模。力学转导对正常和异常发育的影响，如干细胞分化和癌症，也进行了审查。研究阐明了机械传导的多样性，以及它在生物体内稳态中的主要作用。细胞采用多种机制来感知和响应力，这些机制取决于细胞类型和环境。(C)John Wiley & Sons，Inc. WIRES系统生物医学2010 2 625-639
In nearly all aspects of biology, forces are a relevant regulator of life's form and function. More recently, science has established that cells are exquisitely sensitive to forces of varying magnitudes and time scales, and they convert mechanical stimuli into a chemical response. This phenomenon, termed mechanotransduction, is an integral part of cellular physiology and has a profound impact on the development of the organism. Furthermore, malfunctioningmechanical properties or mechanotransduction often leads to pathology of the organism. In this review, we describe mechanotransduction and the theories underlying how forces may be sensed, from the molecular to organism scale. The influence of mechanotransduction on normal and abnormal development, such as stem cell differentiation and cancer, is also reviewed. Studies illustrate the diversity of mechanotransduction, and the major role it has on organism homeostasis. Cells employ a variety of mechanisms, which differ depending upon cell type and environment, to sense and respond to forces. (C) 2010 John Wiley & Sons, Inc. WIREs Syst Biol Med 2010 2 625-639