Use of rapid diagnostic tests for malaria in an emergency situation after the flood disaster in Mozambique
Use of rapid diagnostic tests for malaria in an emergency situation after the flood disaster in Mozambique
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DOI：
10.1016/j.puhe.2005.11.007
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发表时间：
2006-05-01
期刊：
影响因子：
5.2
通讯作者：
Wakai, S
中科院分区：
文献类型：
--
作者：
Hashizume, M;Kondo, H;Wakai, S
目的：确定在莫桑比克受洪灾影响的流离失所者的紧急情况下，与单独的临床诊断相比，如何通过将恶性疟原虫疟疾快速诊断测试（RDT）与根据发烧的存在或病史进行的临床诊断相结合来改善疟疾的诊断。研究设计：2000 年 2 月飓风“埃琳”袭击莫桑比克 3 周后，在加沙省乔奎区一个村庄的紧急门诊诊所进行了一项横断面研究。方法：选择 130 名患有临床疟疾的 15 岁以下儿童进行 RDT 和荧光显微镜检查，并使用吖啶橙作为参考测试。临床疟疾的诊断是根据最近三天的发热史或就诊时腋温超过37.0℃而做出的。计算两个阳性预测值； RDTs 结合临床诊断和单独临床诊断。结果：RDT 结合发烧或发烧史进行临床诊断的阳性预测值为 87.6% (92/105) (95% CI 80.8-92.8)，而单独临床诊断的阳性预测值为 74.6% (97/130) (95% CI 66.2-81.8)。五名患者被诊断为假阴性。
Objectives: To determine how diagnosis of malaria may be improved by combining the use of rapid diagnostic tests (RDTs) for Plasmodium falciparum malaria with clinical diagnosis by the presence or history of fever compared with clinical diagnosis alone in emergency situations with flood-affected displaced populations in Mozambique. Study design: A cross-sectional study conducted at the emergency outpatient clinic in a village in the Chokwe district of Gaza Province, 3 weeks after Cyclone Eline hit Mozambique in February 2000. Methods: A hundred and thirty children aged less than 15 years with clinical malaria were selected for examination by RDT and fluorescent microscopy using acridine orange as a reference test. The diagnosis of clinical malaria was made by a history of fever in the last three days or axillary temperature above 37.0 degrees C at the time of attending the emergency outpatient clinic. Two positive predictive values were calculated; RDTs combined with clinical diagnosis and clinical diagnosis alone. Results: Positive predictive values of RDTs combined with clinical diagnosis by the presence of fever or history of fever were 87.6% (92/105) (95% confidence interval (CI) 80.8-92.8) compared with 74.6% (97/130) (95% CI 66.2-81.8) for clinical diagnosis atone. Five patients were diagnosed false negative.