Evaluating systems pharmacology models is different from evaluating standard pharmacokinetic-pharmacodynamic models.
Evaluating systems pharmacology models is different from evaluating standard pharmacokinetic-pharmacodynamic models.
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DOI：
10.1038/psp.2013.77
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发表时间：
2014-02-19
影响因子：
3.5
通讯作者：
Agoram, B
中科院分区：
文献类型：
--
作者：
Agoram, B
根据作者最近的经验，似乎有一些混乱，关于所需的步骤，使一个系统药理学模型足以达到预期的目的。本文概述了作者最近发表的关于5-脂氧合酶抑制剂的系统药理学1中使用的模型评估方法，并试图在药物计量学和系统药理学界就这一主题进行讨论。
Based on the author's recent experience, there appears to be some confusion regarding the steps required to qualify a systems pharmacology model as adequate for the intended purpose. This manuscript outlines the model evaluation approach used in the author's recent publication1 on the systems pharmacology of a 5-lipoxygenase inhibitor and is an attempt to generate discussion on this topic within the pharmacometrics and systems pharmacology community.