Indicators of mancozeb exposure in relation to thyroid cancer and neural tube defects in farmers' families
Indicators of mancozeb exposure in relation to thyroid cancer and neural tube defects in farmers' families
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DOI：
10.5271/sjweh.855
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发表时间：
2005-04-01
影响因子：
6.3
通讯作者：
Kristensen, P
中科院分区：
文献类型：
--
作者：
Nordby, KC;Andersen, A;Kristensen, P
目的杀菌剂代森锰锌被怀疑可引起甲状腺癌和神经管缺陷。本研究旨在探讨农民家庭中代森锰锌暴露指标与甲状腺癌和神经管缺陷的关系。方法将挪威国家登记资料与1969-1989年国家农业普查和人口登记资料交叉关联，确定1925 - 1971年出生的农民105 403名女性和131 243名男性，以及他们1952-1991年出生的300 805名可供分析的子女。在医学出生登记中，在1973年5月至1991年4月期间怀孕的102 703名儿童中发现了出生时神经管缺陷（ICD-8 740-742）。同样，到2000年，甲状腺癌（icd - 7194）在癌症登记中得到确认。分别从农业普查和气象测量站获得的1973-1990年农业生产和真菌预报（潮湿和温带天气条件）数据作为代森锰锌接触指标。在泊松回归分析中计算校正后的发病率比或患病率比（PR）估计值和95%置信区间（95% CI）。结果神经管缺损131例，患病率12.8/ 10000例，与马铃薯种植（PR 1.6, 95% CI 1.1 ~ 2.3）和父亲工作100 ~ 500小时/年（PR 1.6, 95% CI 1.1 ~ 2.5）有中度相关性。共发现甲状腺癌319例，其中女性141例（发病率10.2/10万人年），男性79例（发病率3.2/10万人年），子代99例（女性发病率3.4 /10万人年，男性发病率0.6/10万人年）。接触代森锰锌与甲状腺癌无关。结论：代森锰锌暴露与神经管缺陷之间存在中度相关性，而代森锰锌暴露与甲状腺癌之间不存在相关性。
Objectives The fungicide mancozeb has been suspected of causing thyroid cancer and neural tube defects. The aim of the study was to investigate associations of indicators of mancozeb exposure with thyroid cancer and neural tube defects in farmers' families.Methods National registers in Norway, identifying 105 403 female and 131 243 male farmers, born in 19251971, and their 300 805 children available for analyses, born in 1952-1991, were cross-linked with national agricultural censuses, 1969-1989, and the population register. Neural tube defects (ICD-8 740-742) at birth among the 102 703 children conceived between May 1973 and April 1991 were identified in the medical birth register. Likewise thyroid cancer (ICD-7 194) was identified in the cancer register through 2000. Data on farm production and fungal forecasts (humid and temperate weather conditions) in 1973-1990, obtained from agricultural censuses and meteorological measurement stations, respectively, served as the mancozeb exposure indicators. The adjusted rate ratio or prevalence ratio (PR) estimates with 95% confidence intervals (95% CI) were computed in a Poisson regression analysis.Results Neural tube defects (131 cases, prevalence 12.8/10 000 births) was moderately associated with potato cultivation (PR 1.6, 95% CI 1.1-2.3) and paternal work of > 500 hours/year (PR 1.6, 95% CI 1.1-2.5). Altogether 319 thyroid cancer cases were identified: 141 in female farmers (incidence 10.2/100 000 person-years), 79 in male farmers (incidence 3.2/100 000 person-years), and 99 in offspring (female and male incidence 3.4 and 0.6/100 000 person-years, respectively). Mancozeb exposure was not associated with thyroid cancer.Conclusions A moderate association seems to exist between mancozeb exposure and neural tube defects, but not between mancozeb exposure and thyroid cancer.