Mid-upper arm circumference is associated with liver steatosis and fibrosis in patients with metabolic-associated fatty liver disease: A population based observational study.
Mid-upper arm circumference is associated with liver steatosis and fibrosis in patients with metabolic-associated fatty liver disease: A population based observational study.
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DOI：
10.1002/hep4.1990
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发表时间：
2022-09
影响因子：
5.1
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中科院分区：
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代谢性脂肪性肝病（MAFLD）是基于肝脏脂肪变性和代谢性疾病的一系列肝脏疾病。脂肪变性作为MAFLD诊断的核心因素，纤维化作为MAFLD不良结局的主要决定因素，需要简单准确的评估。在这项研究中，我们探讨了中上臂围（MUAC）在评估MAFLD患者肝脂肪变性和纤维化中的意义。我们从2017-2018年国家健康与营养检查调查（NHANES）数据库中纳入了2397例MAFLD病例。用振动控制瞬时弹性成像法测量肝脏脂肪变性和纤维化。人体测量参数、人口学和血清学数据来自NHANES数据库。通过多变量线性回归模型、加权广义加性模型和r平滑曲线拟合评估MUAC与肝脏脂肪变性和纤维化的相关性(模型1:β = 3.3513； 95%可信区间[CI]， 2.7722-3.9304；模型2:β = 3.8492; 95% CI, 3.2441-4.4542；模型3:β = 2.4987；95% CI, 1.8371-3.1604)，这种正相关在男性和女性以及不同种族群体（墨西哥裔美国人、其他西班牙裔、非西班牙裔白人、黑人、亚洲人和其他种族）中都是一致的。另一方面，在每个多元线性回归模型中，MUAC与肝纤维化呈正相关，并且这种正相关在男性和女性以及非西班牙裔白人和黑人人群中也是一致的。MUAC升高与MAFLD患者肝脂肪变性和纤维化呈正相关。对于MUAC≥42.0 cm的患者尤其如此。MUAC可能是一种简单方便的MAFLD评估工具。在MAFLD患者中上臂围（MUAC）与肝脂肪变性和纤维化呈正相关（尤其是MUAC≥42cm）。MUAC可作为门诊初次会诊时简单可得的数据，可能是一种简单方便的评估MAFLD的工具。
Metabolic‐associated fatty liver disease (MAFLD) is a series of liver diseases based on liver steatosis and metabolic disorders. Steatosis, as the core factor in MAFLD diagnosis, and fibrosis, as the major determinant of adverse outcomes of MAFLD, need to be assessed simply and accurately. In this study, we explored the significance of mid‐upper arm circumference (MUAC) in evaluating liver steatosis and fibrosis in patients with MAFLD. We included 2397 cases with MAFLD from the 2017–2018 National Health and Nutrition Examination Surveys (NHANES) database. Liver steatosis and fibrosis were measured by vibration controlled transient elastography. Anthropometric parameters and demographic and serological data were obtained from the NHANES database. The association between MUAC and liver steatosis and fibrosis were evaluated by a multivariable linear regression model, a weighted generalized additive model, and smooth curve fitting using R. MUAC was positively associated with liver steatosis in every multivariate linear regression model (model 1: β = 3.3513; 95% confidence interval [CI], 2.7722–3.9304; model 2: β = 3.8492; 95% CI, 3.2441–4.4542; model 3: β = 2.4987; 95% CI, 1.8371–3.1604), and this positive association was consistent in both men and women and among different race groups (Mexican American, other Hispanic, non‐Hispanic White, Black, Asian, and other race). On the other hand, MUAC was positively associated with liver fibrosis in every multivariate linear regression model, and this positive association also was consistent in both men and women and among non‐Hispanic White and Black populations. Increased MUAC was positively associated with liver steatosis and fibrosis in patients with MAFLD. This was particularly true for MUAC ≥ 42.0 cm. MUAC might be a simple and convenient evaluation tool for MAFLD. Mid‐upper arm circumference (MUAC) was positively associated with liver steatosis and fibrosis (especially MUAC ≥42cm) in MAFLD patients. As a simply available data during an initial consultation in the outpatient, MUAC might be a simple and convenient tool in MAFLD assessment.