Cobalt-Catalyzed Cross-Coupling of 3-and 4-Iodopiperidines with Grignard Reagents
Cobalt-Catalyzed Cross-Coupling of 3-and 4-Iodopiperidines with Grignard Reagents
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DOI：
10.1002/chem.201501543
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发表时间：
2015-09-01
影响因子：
4.3
通讯作者：
Cossy, Janine
中科院分区：
文献类型：
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作者：
Gonnard, Laurine;Guerinot, Amandine;Cossy, Janine
公开了3-和4-碘哌啶与格氏试剂之间的钴催化的交叉偶联。该反应是一种高效、廉价、化学选择性和灵活的哌啶官能化方法。该偶联反应被用作实现（+/-）-前拉莫的短合成的关键步骤。进行了一些机理研究，突出了自由基中间体的形成。
A cobalt-catalyzed cross-coupling between 3- and 4-iodopiperidines and Grignard reagents is disclosed. The reaction is an efficient, cheap, chemoselective, and flexible way to functionalize piperidines. This coupling was used as the key step to realize a short synthesis of (+/-)-preclamol. Some mechanistic investigations were conducted that highlight the formation of radical intermediates.