Effect of long-term postoperative interferon therapy on intrahepatic recurrence and survival rate after resection of hepatitis C virus-related hepatocellular carcinoma
Effect of long-term postoperative interferon therapy on intrahepatic recurrence and survival rate after resection of hepatitis C virus-related hepatocellular carcinoma
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DOI：
10.1159/000082098
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发表时间：
2005-01-01
期刊：
影响因子：
4.6
通讯作者：
Kubo, S
中科院分区：
文献类型：
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作者：
Nishiguchi, S;Tamori, A;Kubo, S
目的：探讨干扰素-α对肝细胞癌切除术后生存率的影响。方法：在日本大阪大学医院、医学中心和附属医院进行的一项随机对照试验中，30名男性术后随机分为干扰素-α组(15例)和对照组。干扰素组每天肌注干扰素6mIU，疗程2周，然后每周3次，疗程14周，最后每周2次，疗程88周。观察两组的复发率和生存率。结果：干扰素治疗后持续病毒应答(SVR)2例，生化应答(BR)6例，部分应答(PR)5例，无应答(NR)2例。对照组15例中8例ALT持续异常升高。研究结束时，干扰素组有9例出现肝内复发，对照组有13例出现肝内复发(p=0.065，对数等级检验)。干扰素组的累积存活率高于对照组(p=0.041)。结论：术后干扰素治疗可改善丙型肝炎病毒相关性肝细胞癌切除术后的预后。版权所有(C)2005 S.Karger AG，巴塞尔。
Objective: This study was aimed at evaluating the effects of interferon (IFN)-alpha on survival rate after resection of hepatocellular carcinoma. Methods: In a randomized, controlled trial by the University Hospital, Medical Center and affiliated hospital in Osaka, Japan, 30 men were after surgery randomly allocated to an IFN-alpha group (15 patients) and to a control group. Patients in the IFN group received 6 MIU of IFN-alpha intramuscularly daily for 2 weeks, then three times a week for 14 weeks, and finally twice a week for 88 weeks. The incidence of recurrence and survival rate were then studied. Results: The response to IFN was sustained viral response (SVR) in 2 patients, biochemical response (BR) in 6, partial response (PR) in 5, and no response (NR) in 2. In the control, 8 of the 15 patients demonstrated continuous abnormally high levels of ALT. At the end point of the study, intrahepatic recurrence was detected in 9 of the IFN group and in 13 of the control (p = 0.065, log-rank test). The cumulative survival rate was higher in the IFN group than in the controls (p = 0.041). Conclusion: Postoperative IFN therapy improves the outcome after resection of hepatitis C virus-related hepatocellular carcinoma. Copyright (C) 2005 S. Karger AG, Basel.