THE FUNCTION OF KGF IN MORPHOGENESIS OF EPITHELIUM AND REEPITHELIALIZATION OF WOUNDS
THE FUNCTION OF KGF IN MORPHOGENESIS OF EPITHELIUM AND REEPITHELIALIZATION OF WOUNDS
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DOI：
10.1126/science.7973639
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发表时间：
1994-11-04
期刊：
影响因子：
56.9
通讯作者：
WILLIAMS, LT
中科院分区：
文献类型：
--
作者：
WERNER, S;SMOLA, H;WILLIAMS, LT
通过在基底层角质形成细胞中表达显性负性角质形成细胞生长因子受体基因来评价角质形成细胞生长因子在正常皮肤和创伤皮肤中的功能。转基因小鼠的皮肤以表皮萎缩、毛囊异常和真皮过度增厚为特征。在皮肤损伤时，抑制KGF受体信号转导降低了伤口边缘的表皮角质形成细胞的增殖率，导致伤口的再上皮化显著延迟。
The function of keratinocyte growth factor (KGF) in normal and wounded skin was assessed by expression of a dominant-negative KGF receptor transgene in basal keratinocytes. The skin of transgenic mice was characterized by epidermal atrophy, abnormalities in the hair follicles, and dermal hyperthickening. Upon skin injury, inhibition of KGF receptor signaling reduced the proliferation rate of epidermal keratinocytes at the wound edge, resulting in substantially delayed reepithelialization of the wound.